Reactome Pathway Database

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Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation Show undefined attributes

catalystActivity

[CatalystActivity:10297124] ubiquitin-protein transferase activity of ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10201029] Weiser, Joel, 2025年08月27日

dbId 10297126

displayName Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation

eventOf

[Pathway:R-CFA-9645460] Alpha-protein kinase 1 signaling pathway - Canis familiaris

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-CFA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Canis familiaris

inferredFrom

[Polymerisation:R-HSA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Homo sapiens

input

[DefinedSet:R-CFA-113595] Ub [cytosol]

isInDisease false

isInferred true

maxDepth 1

name

Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation

output

[Polymer:R-CFA-450152] K63polyUb [cytosol]

precedingEvent

[BlackBoxEvent:R-CFA-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Canis familiaris

releaseDate 2025年09月18日

schemaClass Polymerisation

species

[Species:49646] Canis familiaris

stId R-CFA-9645394

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CFA-9645460] Alpha-protein kinase 1 signaling pathway

(precedingEvent)

[Reaction:R-CFA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)

(inferredTo)

[Polymerisation:R-HSA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation

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