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Schema
>
Reaction
>
Entries
Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
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authored
[InstanceEdit:450360] Shamovsky, V, 2009年12月16日
category
binding
compartment
[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created
[InstanceEdit:177688] Gillespie, ME, 2006年04月04日 05:49:12
dbId
177690
displayName
Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
edited
[InstanceEdit:450323] Shamovsky, V, 2009年12月16日
eventOf
[Pathway:R-HSA-9014325] TICAM1,TRAF6-dependent induction of TAK1 complex - Homo sapiens
followingEvent
[Reaction:R-HSA-177692] Activation of recruited TAK1 within the activated TLR3 complex - Homo sapiens
input
2 ×
[Polymer:R-HSA-450152] K63polyUb [cytosol]
2 ×
[Complex:R-HSA-450277] TAB1:TAB2,TAB3:TAK1 [cytosol]
[Complex:R-HSA-450309] viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains
[LiteratureReference:177899] Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR
[LiteratureReference:208226] TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
[LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
orthologousEvent
[Reaction:R-GGA-433950] TRAF6 recruits TAK1 kinase complex - Gallus gallus
output
[Complex:R-HSA-177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane]
precedingEvent
[Polymerisation:R-HSA-9628444] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation - Homo sapiens
relatedSpecies
[Species:5229092] Hepatitis B virus
[Species:5621375] Hepatitis C Virus
[Species:5689680] Human herpesvirus 1
[Species:5617433] Rotavirus
[Species:9031716] Influenza A virus
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:188961] Gay, NJ, 2006年04月24日 16:48:17
[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012年11月13日
revised
[InstanceEdit:450360] Shamovsky, V, 2009年12月16日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-177690
summation
[Summation:450280] TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...
updateTrackers
[UpdateTracker:9788994] Update Tracker - [Reaction:177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex - v39:[add_removeCatalystActivity]
[UpdateTracker:9791134] Update Tracker - [Reaction:177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex - v32:[addCatalystActivity, addLiteratureReference, add_removeInput, add_removeSummation]
Referrals
(updatedInstance)
[UpdateTracker:9788994] Update Tracker - [Reaction:177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex - v39:[add_removeCatalystActivity]
[UpdateTracker:9791134] Update Tracker - [Reaction:177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex - v32:[addCatalystActivity, addLiteratureReference, add_removeInput, add_removeSummation]
(hasEvent)
[Pathway:R-HSA-9014325] TICAM1,TRAF6-dependent induction of TAK1 complex
(precedingEvent)
[Reaction:R-HSA-177692] Activation of recruited TAK1 within the activated TLR3 complex
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