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Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation Show undefined attributes

authored

[InstanceEdit:1094913] Shamovsky, V, 2010年11月30日

category binding

compartment

created [InstanceEdit:573295] Shamovsky, V, 2010年04月09日

dbId 573296

displayName Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation

edited

[InstanceEdit:1221606] Shamovsky, V, 2011年02月24日

eventOf

[Pathway:R-GGA-573298] NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation - Gallus gallus

followingEvent

[Reaction:R-GGA-994000] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation - Gallus gallus

inferredFrom

[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens

input

isInDisease false

isInferred true

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation

output

[Complex:R-GGA-993989] p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane]

precedingEvent

releaseDate 2011年03月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:1112618] D'Eustachio, P, 2010年12月06日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-573296

summation

[Summation:434094] Polyubiquitinated TRAF6 activates TAK1 by binding to the ubi...

Referrals

(hasEvent)

[Pathway:R-GGA-573298] NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation

(precedingEvent)

[Reaction:R-GGA-994000] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation

(inferredTo)

[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation

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