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Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 Show undefined attributes

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authored

[InstanceEdit:451590] Shamovsky, V, 2010年01月05日

catalystActivity

[CatalystActivity:451446] ubiquitin-protein transferase activity of oligo TRAF6 : p-IRAK2 [plasma membrane]

category omitted

compartment

created [InstanceEdit:451437] Shamovsky, V, 2010年01月05日

dbId 451470

displayName Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6

edited

[InstanceEdit:994006] Shamovsky, V, 2010年11月05日

eventOf

[Pathway:R-GGA-433822] NFkB and MAPK activation mediated by TRAF6 - Gallus gallus

followingEvent

[Reaction:R-GGA-451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex - Gallus gallus

goBiologicalProcess [GO_BiologicalProcess:436928] free ubiquitin chain polymerization

inferredFrom

[Polymerisation:R-HSA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Homo sapiens

input

3 × [DefinedSet:R-GGA-434147] Ubiquitin [cytosol]

isInDisease false

isInferred true

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6

output

[Polymer:R-GGA-451962] free K63_polyubiquitin chain [cytosol]

precedingEvent

[BlackBoxEvent:R-GGA-451450] Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 - Gallus gallus

releaseDate 2010年12月14日

requiredInputComponent

[Complex:R-GGA-433960] UBE2N : UBE2V complex [cytosol] - Gallus gallus

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:977269] D'Eustachio, P, 2010年10月15日

schemaClass BlackBoxEvent

species

[Species:49591] Gallus gallus

stId R-GGA-451470

summation

[Summation:446233] TRAF6 generates unanchored Lys63-linked polyubiquitin chains...

Referrals

(hasEvent)

[Pathway:R-GGA-433822] NFkB and MAPK activation mediated by TRAF6

(precedingEvent)

[Reaction:R-GGA-451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex

(inferredTo)

[Polymerisation:R-HSA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains

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