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Schema
>
Polymerisation
>
Entries
Activated TRAF6 synthesizes unanchored polyubiquitin chains
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authored
[InstanceEdit:847735] Shamovsky, V, 2010年06月01日
catalystActivity
[CatalystActivity:8947977] ubiquitin-protein transferase activity of p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:936971] Shamovsky, V, 2010年08月25日
dbId
936986
displayName
Activated TRAF6 synthesizes unanchored polyubiquitin chains
edited
[InstanceEdit:2562589] Shamovsky, V, 2012年11月06日
eventOf
[Pathway:R-HSA-937042] IRAK2 mediated activation of TAK1 complex - Homo sapiens
followingEvent
[Reaction:R-HSA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Homo sapiens
input
[DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Activated TRAF6 synthesizes unanchored polyubiquitin chains
orthologousEvent
[BlackBoxEvent:R-GGA-451470] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 - Gallus gallus
[Polymerisation:R-DME-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Drosophila melanogaster
[Polymerisation:R-GGA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Gallus gallus
[Polymerisation:R-SSC-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Sus scrofa
[Polymerisation:R-BTA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Bos taurus
[Polymerisation:R-CFA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Canis familiaris
[Polymerisation:R-RNO-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Rattus norvegicus
[Polymerisation:R-MMU-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Mus musculus
output
[Polymer:R-HSA-450152] K63polyUb [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Homo sapiens
releaseDate
2010年12月14日
requiredInputComponent
[EntityWithAccessionedSequence:R-HSA-174100] UBE2E1 [cytosol] - Homo sapiens
[Complex:R-HSA-202463] UBE2N:UBE2V1 [cytosol] - Homo sapiens
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1095192] Gillespie, ME, 2010年11月30日
[InstanceEdit:2603254] Napetschnig, Johanna, 2012年11月16日
[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012年11月13日
schemaClass
Polymerisation
species
[Species:48887] Homo sapiens
stId
R-HSA-936986
summation
[Summation:450260] Polyubiquitinated TRAF6 (as E3 ubiquitin ligase) generates f...
updateTrackers
[UpdateTracker:9788651] Update Tracker - [Polymerisation:936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - v41:[add_removeCatalystActivity]
[UpdateTracker:9782571] Update Tracker - [Polymerisation:936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - v59:[add_removeCatalystActivity]
Referrals
(updatedInstance)
[UpdateTracker:9788651] Update Tracker - [Polymerisation:936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - v41:[add_removeCatalystActivity]
[UpdateTracker:9782571] Update Tracker - [Polymerisation:936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - v59:[add_removeCatalystActivity]
(hasEvent)
[Pathway:R-HSA-937042] IRAK2 mediated activation of TAK1 complex
(precedingEvent)
[Reaction:R-HSA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex
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