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Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 Show undefined attributes

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authored

[InstanceEdit:434153] Shamovsky, V, 2009年08月26日

catalystActivity

[CatalystActivity:433906] ubiquitin-protein transferase activity of viral ds RNA : TLR3 : TICAM1 : pUb-TRAF6 [endosome membrane]

category omitted

compartment

created [InstanceEdit:434122] Shamovsky, V, 2009年08月26日

dbId 433936

displayName Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1

edited

[InstanceEdit:668815] Shamovsky, V, 2010年05月04日

eventOf

[Pathway:R-GGA-433871] TRAF6 mediated induction of proinflammatory cytokines - Gallus gallus

followingEvent

[Reaction:R-GGA-433950] TRAF6 recruits TAK1 kinase complex - Gallus gallus

goBiologicalProcess [GO_BiologicalProcess:436928] free ubiquitin chain polymerization

inferredFrom

[Polymerisation:R-HSA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Homo sapiens

input

3 × [DefinedSet:R-GGA-434147] Ubiquitin [cytosol]

isInDisease false

isInferred true

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1

output

[Polymer:R-GGA-451962] free K63_polyubiquitin chain [cytosol]

precedingEvent

[BlackBoxEvent:R-GGA-433981] Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 - Gallus gallus

relatedSpecies

[Species:9014381] Infectious bronchitis virus

releaseDate 2010年12月14日

requiredInputComponent

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:789693] D'Eustachio, P, 2010年05月23日

schemaClass BlackBoxEvent

species

[Species:49591] Gallus gallus

stId R-GGA-433936

summation

[Summation:446233] TRAF6 generates unanchored Lys63-linked polyubiquitin chains...

Referrals

(hasEvent)

[Pathway:R-GGA-433871] TRAF6 mediated induction of proinflammatory cytokines

(precedingEvent)

[Reaction:R-GGA-433950] TRAF6 recruits TAK1 kinase complex

(inferredTo)

[Polymerisation:R-HSA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation

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