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Entries
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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compartment
[Compartment:984] extracellular region
created
[InstanceEdit:381505] May, B, 2008年11月19日 20:29:10
dbId
381426
deleted
[Deleted:2980740] Deletion of instance: 381150
displayName
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
edited
[InstanceEdit:381443] May, B, Gopinathrao, G, 2008年11月19日 20:02:07
eventOf
[TopLevelPathway:R-HSA-392499] Metabolism of proteins - Homo sapiens
figure
[Figure:387446] /figures/Firth2002-IGFBPaction.jpg
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-381487] IGFBP1 binds IGF forming IGF:IGFBP1 - Homo sapiens
[Reaction:R-HSA-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Homo sapiens
[Reaction:R-HSA-381496] Formation of the IGF:IGFBP3:ALS complex - Homo sapiens
[Reaction:R-HSA-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Homo sapiens
[Reaction:R-HSA-381545] Formation of the IGF:IGFBP5:ALS complex - Homo sapiens
[Reaction:R-HSA-381503] IGFBP6 binds IGF forming IGF:IGFBP6 - Homo sapiens
[Reaction:R-HSA-381500] Cathepsin G proteolyzes IGF:IGFBP3:ALS - Homo sapiens
[Reaction:R-HSA-381435] Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS - Homo sapiens
[Reaction:R-HSA-381461] Plasmin proteolyzes IGF:IGFBP-3:ALS - Homo sapiens
[Reaction:R-HSA-381466] Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS - Homo sapiens
[Reaction:R-HSA-381446] Thrombin proteolyzes IGF:IGFBP3:ALS - Homo sapiens
[Reaction:R-HSA-381518] PAAP-A proteolyzes IGF:IGFBP4 - Homo sapiens
[Reaction:R-HSA-381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS - Homo sapiens
[Reaction:R-HSA-8952289] FAM20C phosphorylates FAM20C substrates - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2018年03月26日
literatureReference
[LiteratureReference:381400] Cellular actions of the insulin-like growth factor binding proteins
[LiteratureReference:381419] Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter?
[LiteratureReference:381407] IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
[LiteratureReference:381401] The role of insulin-like growth factor binding proteins
[LiteratureReference:381493] IGF-binding protein-4: biochemical characteristics and functional consequences
[LiteratureReference:381476] Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells
maxDepth
2
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Regulation of IGF Activity by IGFBP
orthologousEvent
[Pathway:R-MMU-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Mus musculus
[Pathway:R-CEL-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Caenorhabditis elegans
[Pathway:R-DME-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Drosophila melanogaster
[Pathway:R-GGA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Gallus gallus
[Pathway:R-XTR-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Xenopus tropicalis
[Pathway:R-DRE-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Danio rerio
[Pathway:R-SSC-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Sus scrofa
[Pathway:R-BTA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Bos taurus
[Pathway:R-CFA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Canis familiaris
[Pathway:R-RNO-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Rattus norvegicus
releaseDate
2008年12月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008年12月02日 16:25:31
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-381426
summation
[Summation:381411] The family of Insulin like Growth Factor Binding Proteins (I...
updateTrackers
[UpdateTracker:9780094] Update Tracker - [Pathway:381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - v64:[updateContainedRLE]
[UpdateTracker:9781864] Update Tracker - [Pathway:381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - v60:[addHasEvent]
[UpdateTracker:9790426] Update Tracker - [Pathway:381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - v33:[updateContainedRLE]
[UpdateTracker:9787136] Update Tracker - [Pathway:381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - v46:[modifyText, updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9780094] Update Tracker - [Pathway:381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - v64:[updateContainedRLE]
[UpdateTracker:9781864] Update Tracker - [Pathway:381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - v60:[addHasEvent]
[UpdateTracker:9790426] Update Tracker - [Pathway:381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - v33:[updateContainedRLE]
[UpdateTracker:9787136] Update Tracker - [Pathway:381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - v46:[modifyText, updateContainedRLE]
(replacementInstances)
[Deleted:2980740] Deletion of instance: 381150
(hasEvent)
[TopLevelPathway:R-HSA-392499] Metabolism of proteins
(hasEncapsulatedEvent)
[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes
[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
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