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Schema
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Entries
IGFBP4 binds IGF forming IGF:IGFBP4
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category
binding
compartment
[Compartment:984] extracellular region
created
[InstanceEdit:381505] May, B, 2008年11月19日 20:29:10
dbId
381543
displayName
IGFBP4 binds IGF forming IGF:IGFBP4
edited
[InstanceEdit:381443] May, B, Gopinathrao, G, 2008年11月19日 20:02:07
eventOf
[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Homo sapiens
followingEvent
[Reaction:R-HSA-381518] PAAP-A proteolyzes IGF:IGFBP4 - Homo sapiens
input
[DefinedSet:R-HSA-381451] IGF1,2 [extracellular region]
[EntityWithAccessionedSequence:R-HSA-381421] IGFBP4 [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:535671] Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6
[LiteratureReference:535663] Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes
[LiteratureReference:535695] Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography
[LiteratureReference:535650] Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting
[LiteratureReference:381493] IGF-binding protein-4: biochemical characteristics and functional consequences
[LiteratureReference:538706] Structural basis for the regulation of insulin-like growth factors by IGF binding proteins
[LiteratureReference:381400] Cellular actions of the insulin-like growth factor binding proteins
[LiteratureReference:381407] IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
[LiteratureReference:381401] The role of insulin-like growth factor binding proteins
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
IGFBP4 binds IGF forming IGF:IGFBP4
orthologousEvent
[Reaction:R-MMU-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Mus musculus
[Reaction:R-GGA-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Gallus gallus
[Reaction:R-XTR-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Xenopus tropicalis
[Reaction:R-SSC-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Sus scrofa
[Reaction:R-BTA-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Bos taurus
[Reaction:R-CFA-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Canis familiaris
[Reaction:R-RNO-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Rattus norvegicus
output
[Complex:R-HSA-381509] IGF:IGFBP4 [extracellular region]
releaseDate
2008年12月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008年12月02日 16:25:31
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-381543
summation
[Summation:381549] IGFBP 4 binds IGF I or IGF II via the conserved N terminus a...
updateTrackers
[UpdateTracker:9790513] Update Tracker - [Reaction:381543] IGFBP4 binds IGF forming IGF:IGFBP4 - v33:[add_removeLiteratureReference]
[UpdateTracker:9779758] Update Tracker - [Reaction:381543] IGFBP4 binds IGF forming IGF:IGFBP4 - v64:[removeCatalystActivity]
Referrals
(updatedInstance)
[UpdateTracker:9790513] Update Tracker - [Reaction:381543] IGFBP4 binds IGF forming IGF:IGFBP4 - v33:[add_removeLiteratureReference]
[UpdateTracker:9779758] Update Tracker - [Reaction:381543] IGFBP4 binds IGF forming IGF:IGFBP4 - v64:[removeCatalystActivity]
(hasEvent)
[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
(precedingEvent)
[Reaction:R-HSA-381518] PAAP-A proteolyzes IGF:IGFBP4
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