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Reaction
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Entries
Formation of the IGF:IGFBP5:ALS complex
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category
binding
compartment
[Compartment:984] extracellular region
created
[InstanceEdit:381505] May, B, 2008年11月19日 20:29:10
dbId
381545
displayName
Formation of the IGF:IGFBP5:ALS complex
edited
[InstanceEdit:381443] May, B, Gopinathrao, G, 2008年11月19日 20:02:07
eventOf
[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Homo sapiens
followingEvent
[Reaction:R-HSA-381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS - Homo sapiens
input
[DefinedSet:R-HSA-381451] IGF1,2 [extracellular region]
[EntityWithAccessionedSequence:R-HSA-381498] IGFALS [extracellular region]
[EntityWithAccessionedSequence:R-HSA-381414] IGFBP5 [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:381441] Molecular distribution of IGF binding protein-5 in human serum
[LiteratureReference:535671] Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6
[LiteratureReference:535663] Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes
[LiteratureReference:535695] Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography
[LiteratureReference:535650] Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting
[LiteratureReference:535686] The role of the acid-labile subunit in regulating insulin-like growth factor transport across human umbilical vein endothelial cell monolayers
[LiteratureReference:535690] Mutagenesis of basic amino acids in the carboxyl-terminal region of insulin-like growth factor binding protein-5 affects acid-labile subunit binding
[LiteratureReference:535657] Binding characteristics of pro-insulin-like growth factor-II from cancer patients: binary and ternary complex formation with IGF binding proteins-1 to -6
[LiteratureReference:535681] A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit
[LiteratureReference:535679] Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain
[LiteratureReference:535677] Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit
[LiteratureReference:381400] Cellular actions of the insulin-like growth factor binding proteins
[LiteratureReference:381407] IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
[LiteratureReference:381401] The role of insulin-like growth factor binding proteins
maxDepth
1
modified
[InstanceEdit:10541496] Weiser, Joel, 2025年08月27日
name
Formation of the IGF:IGFBP5:ALS complex
orthologousEvent
[Reaction:R-DRE-381545] Formation of the IGF:IGFBP5:ALS complex - Danio rerio
[Reaction:R-RNO-381545] Formation of the IGF:IGFBP5:ALS complex - Rattus norvegicus
output
[Complex:R-HSA-381423] IGF:IGFBP5:ALS [extracellular region]
releaseDate
2008年12月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008年12月02日 16:25:31
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-381545
summation
[Summation:381548] IGFBP 5 binds IGF I or IGF II via the conserved N terminus a...
updateTrackers
[UpdateTracker:9779923] Update Tracker - [Reaction:381545] Formation of the IGF:IGFBP5:ALS complex - v64:[removeCatalystActivity]
[UpdateTracker:9790349] Update Tracker - [Reaction:381545] Formation of the IGF:IGFBP5:ALS complex - v33:[add_removeLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9779923] Update Tracker - [Reaction:381545] Formation of the IGF:IGFBP5:ALS complex - v64:[removeCatalystActivity]
[UpdateTracker:9790349] Update Tracker - [Reaction:381545] Formation of the IGF:IGFBP5:ALS complex - v33:[add_removeLiteratureReference]
(hasEvent)
[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
(precedingEvent)
[Reaction:R-HSA-381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS
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