Reactome Pathway Database

Schema > Reaction > Entries

PAPP-A2 proteolyzes IGF:IGFBP5:ALS Show undefined attributes

catalystActivity

[CatalystActivity:381438] metalloendopeptidase activity of PAPPA,PAPPA2 [extracellular region]

category transition

compartment

[Compartment:984] extracellular region

created [InstanceEdit:381505] May, B, 2008年11月19日 20:29:10

dbId 381537

displayName PAPP-A2 proteolyzes IGF:IGFBP5:ALS

edited

[InstanceEdit:381443] May, B, Gopinathrao, G, 2008年11月19日 20:02:07

eventOf

[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Homo sapiens

input

[Complex:R-HSA-381423] IGF:IGFBP5:ALS [extracellular region]

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10541496] Weiser, Joel, 2025年08月27日

name

PAPP-A2 proteolyzes IGF:IGFBP5:ALS

orthologousEvent

output

precedingEvent

[Reaction:R-HSA-381545] Formation of the IGF:IGFBP5:ALS complex - Homo sapiens

releaseDate 2008年12月17日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008年12月02日 16:25:31

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-381537

summation

[Summation:381422] Both Pregnancy Associated Plasma Protein A (PAPP-A) and A2 (...

updateTrackers

[UpdateTracker:9790756] Update Tracker - [Reaction:381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS - v33:[modifyText, removeLiteratureReference, removeOutput]

Referrals

(updatedInstance)

[UpdateTracker:9790756] Update Tracker - [Reaction:381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS - v33:[modifyText, removeLiteratureReference, removeOutput]

(hasEvent)

[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

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