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IGFBP2 binds IGF forming IGF:IGFBP2
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category
binding
compartment
[Compartment:984] extracellular region
created
[InstanceEdit:381505] May, B, 2008年11月19日 20:29:10
dbId
381412
displayName
IGFBP2 binds IGF forming IGF:IGFBP2
edited
[InstanceEdit:381443] May, B, Gopinathrao, G, 2008年11月19日 20:02:07
eventOf
[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Homo sapiens
input
[DefinedSet:R-HSA-381451] IGF1,2 [extracellular region]
[EntityWithAccessionedSequence:R-HSA-381402] IGFBP2 [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:535634] Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)
[LiteratureReference:535671] Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6
[LiteratureReference:535668] Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding
[LiteratureReference:535663] Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes
[LiteratureReference:535655] Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation
[LiteratureReference:381459] Effects of IGFBP-2 overexpression in vitro and in vivo
[LiteratureReference:535650] Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting
[LiteratureReference:381400] Cellular actions of the insulin-like growth factor binding proteins
[LiteratureReference:381419] Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter?
[LiteratureReference:381407] IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
[LiteratureReference:381401] The role of insulin-like growth factor binding proteins
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
IGFBP2 binds IGF forming IGF:IGFBP2
orthologousEvent
[Reaction:R-MMU-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Mus musculus
[Reaction:R-GGA-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Gallus gallus
[Reaction:R-XTR-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Xenopus tropicalis
[Reaction:R-DRE-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Danio rerio
[Reaction:R-SSC-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Sus scrofa
[Reaction:R-BTA-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Bos taurus
[Reaction:R-CFA-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Canis familiaris
[Reaction:R-RNO-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Rattus norvegicus
output
[Complex:R-HSA-381473] IGF:IGFBP2 [extracellular region]
releaseDate
2008年12月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008年12月02日 16:25:31
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-381412
summation
[Summation:381494] IGFBP 2 binds IGF I or IGF II via the conserved N terminus a...
updateTrackers
[UpdateTracker:9790758] Update Tracker - [Reaction:381412] IGFBP2 binds IGF forming IGF:IGFBP2 - v33:[add_removeLiteratureReference]
[UpdateTracker:9779798] Update Tracker - [Reaction:381412] IGFBP2 binds IGF forming IGF:IGFBP2 - v64:[removeCatalystActivity]
Referrals
(updatedInstance)
[UpdateTracker:9790758] Update Tracker - [Reaction:381412] IGFBP2 binds IGF forming IGF:IGFBP2 - v33:[add_removeLiteratureReference]
[UpdateTracker:9779798] Update Tracker - [Reaction:381412] IGFBP2 binds IGF forming IGF:IGFBP2 - v64:[removeCatalystActivity]
(hasEvent)
[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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