Reactome Pathway Database

Schema > Reaction > Entries

Cathepsin G proteolyzes IGF:IGFBP3:ALS Show undefined attributes

authored

[InstanceEdit:381443] May, B, Gopinathrao, G, 2008年11月19日 20:02:07

catalystActivity

[CatalystActivity:381447] serine-type endopeptidase activity of Cathepsin G [plasma membrane]

catalystActivityReference [CatalystActivityReference:9643446] serine-type endopeptidase activity of Cathepsin G [plasma membrane] Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases

category transition

compartment

created [InstanceEdit:381505] May, B, 2008年11月19日 20:29:10

dbId 381500

displayName Cathepsin G proteolyzes IGF:IGFBP3:ALS

edited

eventOf

[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Homo sapiens

input

[Complex:R-HSA-381536] IGF:IGFBP3:ALS [extracellular region]

isInDisease false

isInferred false

literatureReference

[LiteratureReference:538771] Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases

maxDepth 1

modified [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

name

Cathepsin G proteolyzes IGF:IGFBP3:ALS

orthologousEvent

[Reaction:R-RNO-381500] Cathepsin G proteolyzes IGF:IGFBP3:ALS - Rattus norvegicus

output

precedingEvent

[Reaction:R-HSA-381496] Formation of the IGF:IGFBP3:ALS complex - Homo sapiens

releaseDate 2008年12月17日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008年12月02日 16:25:31

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-381500

summation

[Summation:381463] Cathepsin G cleaves IGFBP-3 between amino acids 168 and 169 ...

updateTrackers

[UpdateTracker:9790680] Update Tracker - [Reaction:381500] Cathepsin G proteolyzes IGF:IGFBP3:ALS - v33:[addLiteratureReference, addOutput, modifyText]

Referrals

(updatedInstance)

[UpdateTracker:9790680] Update Tracker - [Reaction:381500] Cathepsin G proteolyzes IGF:IGFBP3:ALS - v33:[addLiteratureReference, addOutput, modifyText]

(hasEvent)

[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

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