Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
TP53 Regulates Transcription of Cell Death Genes
Show undefined attributes
Go to Details
authored
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日
created
[InstanceEdit:5633006] Orlic-Milacic, Marija, 2014年10月29日
dbId
5633008
displayName
TP53 Regulates Transcription of Cell Death Genes
doi
10.3180/r-hsa-5633008.1
edited
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日
eventOf
[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53 - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:139812] regulation of apoptotic process
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-6803211] TP53 Regulates Transcription of Death Receptors and Ligands - Homo sapiens
[Pathway:R-HSA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Homo sapiens
[Pathway:R-HSA-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases - Homo sapiens
[Pathway:R-HSA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2016年06月27日
literatureReference
[LiteratureReference:5633431] KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
[LiteratureReference:5633440] Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site
[LiteratureReference:5633427] Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene
[LiteratureReference:5633411] p53 upregulates death receptor 4 expression through an intronic p53 binding site
[LiteratureReference:5633426] Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site
[LiteratureReference:5633429] Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity
[LiteratureReference:6799811] Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family
[LiteratureReference:6799802] ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo
[LiteratureReference:3700985] Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
[LiteratureReference:140387] Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
[LiteratureReference:6799772] ASPP proteins specifically stimulate the apoptotic function of p53
[LiteratureReference:140450] PUMA, a novel proapoptotic gene, is induced by p53
[LiteratureReference:6791288] BID regulation by p53 contributes to chemosensitivity
[LiteratureReference:6801169] The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase
[LiteratureReference:6799791] ASPP1 and ASPP2: common activators of p53 family members
[LiteratureReference:140442] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53
[LiteratureReference:6800029] Induction of the growth inhibitor IGF-binding protein 3 by p53
[LiteratureReference:6800045] Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer
[LiteratureReference:6798000] Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth
[LiteratureReference:6791300] AMID is a p53-inducible gene downregulated in tumors
[LiteratureReference:6801207] p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway
[LiteratureReference:6799790] Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax
[LiteratureReference:6800007] iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes
[LiteratureReference:6800275] Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis
[LiteratureReference:6791355] APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis
[LiteratureReference:6798096] Direct transcriptional activation of human caspase-1 by tumor suppressor p53
[LiteratureReference:6798128] Apoptotic threshold is lowered by p53 transactivation of caspase-6
[LiteratureReference:6798143] Caspase 10 levels are increased following DNA damage in a p53-dependent manner
[LiteratureReference:6801360] Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis
[LiteratureReference:451670] Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death
[LiteratureReference:6800838] PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family
[LiteratureReference:6791335] Bcl-G, a novel pro-apoptotic member of the Bcl-2 family
[LiteratureReference:6799447] A polymorphic microsatellite that mediates induction of PIG3 by p53
[LiteratureReference:6800842] Perp is a p63-regulated gene essential for epithelial integrity
[LiteratureReference:5633302] NDRG1 is necessary for p53-dependent apoptosis
[LiteratureReference:6800259] The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
[LiteratureReference:5628898] Identification of novel p53 target genes in ionizing radiation response
[LiteratureReference:6800261] BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma
[LiteratureReference:5633304] p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion
[LiteratureReference:6800238] BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma
[LiteratureReference:6800848] P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma
[LiteratureReference:6791332] Bcl-2 family member Bcl-G is not a proapoptotic protein
[LiteratureReference:6798366] DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage
[LiteratureReference:3215254] p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis
[LiteratureReference:3215228] TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity
[LiteratureReference:6798080] Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin
[LiteratureReference:6801427] Perp is a mediator of p53-dependent apoptosis in diverse cell types
[LiteratureReference:6798097] Caspase-1 is a novel target of p63 in tumor suppression
[LiteratureReference:6801440] Transcriptional control of human p53-regulated genes
[LiteratureReference:6801441] A complex barcode underlies the heterogeneous response of p53 to stress
[LiteratureReference:6801433] Unravelling mechanisms of p53-mediated tumour suppression
[LiteratureReference:6801439] p53 in survival, death and metabolic health: a lifeguard with a licence to kill
maxDepth
3
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
TP53 Regulates Transcription of Cell Death Genes
orthologousEvent
[Pathway:R-DME-5633008] TP53 Regulates Transcription of Cell Death Genes - Drosophila melanogaster
[Pathway:R-MMU-5633008] TP53 Regulates Transcription of Cell Death Genes - Mus musculus
[Pathway:R-RNO-5633008] TP53 Regulates Transcription of Cell Death Genes - Rattus norvegicus
[Pathway:R-CFA-5633008] TP53 Regulates Transcription of Cell Death Genes - Canis familiaris
[Pathway:R-BTA-5633008] TP53 Regulates Transcription of Cell Death Genes - Bos taurus
[Pathway:R-SSC-5633008] TP53 Regulates Transcription of Cell Death Genes - Sus scrofa
[Pathway:R-XTR-5633008] TP53 Regulates Transcription of Cell Death Genes - Xenopus tropicalis
[Pathway:R-GGA-5633008] TP53 Regulates Transcription of Cell Death Genes - Gallus gallus
[Pathway:R-DRE-5633008] TP53 Regulates Transcription of Cell Death Genes - Danio rerio
[Pathway:R-CEL-5633008] TP53 Regulates Transcription of Cell Death Genes - Caenorhabditis elegans
[Pathway:R-DDI-5633008] TP53 Regulates Transcription of Cell Death Genes - Dictyostelium discoideum
[Pathway:R-SPO-5633008] TP53 Regulates Transcription of Cell Death Genes - Schizosaccharomyces pombe
[Pathway:R-PFA-5633008] TP53 Regulates Transcription of Cell Death Genes - Plasmodium falciparum
[Pathway:R-SCE-5633008] TP53 Regulates Transcription of Cell Death Genes - Saccharomyces cerevisiae
releaseDate
2016年03月23日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855677] Zaccara, Sara, 2016年02月04日
[InstanceEdit:8855680] Inga, Alberto, 2016年02月04日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5633008
summation
[Summation:6801419] The tumor suppressor TP53 (p53) exerts its tumor suppressive...
updateTrackers
[UpdateTracker:9783309] Update Tracker - [Pathway:5633008] TP53 Regulates Transcription of Cell Death Genes - v57:[updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53
(hasEncapsulatedEvent)
[Pathway:R-HSA-6804759] Regulation of TP53 Activity through Association with Co-factors
[Pathway:R-HSA-6791312] TP53 Regulates Transcription of Cell Cycle Genes
(updatedInstance)
[UpdateTracker:9783309] Update Tracker - [Pathway:5633008] TP53 Regulates Transcription of Cell Death Genes - v57:[updateIndirectRLE]
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル