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Entries
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
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authored
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日
created
[InstanceEdit:6803212] Orlic-Milacic, Marija, 2015年10月05日
crossReference
[DatabaseIdentifier:12758032] BioModels Database:BIOMD0000000287
[DatabaseIdentifier:12758110] BioModels Database:BIOMD0000000188
[DatabaseIdentifier:12757988] BioModels Database:BIOMD0000000939
[DatabaseIdentifier:12758100] BioModels Database:BIOMD0000000943
[DatabaseIdentifier:12757926] BioModels Database:BIOMD0000000940
[DatabaseIdentifier:12758112] BioModels Database:BIOMD0000000634
dbId
6803204
displayName
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
edited
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日
eventOf
[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-3700981] TP53 family members bind the BAX promoter - Homo sapiens
[BlackBoxEvent:R-HSA-3700984] TP53 family members stimulate BAX transcription - Homo sapiens
[Reaction:R-HSA-4331331] TP53 binds the PMAIP1 (NOXA) promoter - Homo sapiens
[BlackBoxEvent:R-HSA-140214] TP53 stimulates PMAIP1 (NOXA) expression - Homo sapiens
[Reaction:R-HSA-4331340] TP53 binds the BBC3 (PUMA) promoter - Homo sapiens
[BlackBoxEvent:R-HSA-139913] TP53 stimulates BBC3 (PUMA) expression - Homo sapiens
[Reaction:R-HSA-6791285] TP53 binds the BID gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-6791291] TP53 stimulates BID gene expression - Homo sapiens
[Reaction:R-HSA-6797993] TP53 and CREBBP bind BNIP3L gene - Homo sapiens
[BlackBoxEvent:R-HSA-6798004] TP53 stimulates BNIP3L expression - Homo sapiens
[Reaction:R-HSA-6798615] TP53 binds the TP53AIP1 gene - Homo sapiens
[BlackBoxEvent:R-HSA-6798611] TP53 stimulates and ZNF420 inhibits TP53AIP1 expression - Homo sapiens
[Reaction:R-HSA-6798624] ZNF420 binds TP53AIP1 gene - Homo sapiens
[Reaction:R-HSA-6799097] ATM phosphorylates ZNF420 - Homo sapiens
[Reaction:R-HSA-6801166] TP53 binds the STEAP3 gene - Homo sapiens
[BlackBoxEvent:R-HSA-6801184] TP53 stimulates STEAP3 expression - Homo sapiens
[Reaction:R-HSA-6801195] STEAP3 binds BNIP3L - Homo sapiens
[Reaction:R-HSA-6801209] TP53 binds the TRIAP1 gene - Homo sapiens
[BlackBoxEvent:R-HSA-6801213] TP53 stimulates TRIAP1 expression - Homo sapiens
[Reaction:R-HSA-6801242] TRIAP1 binds PRELID1, PRELID3A - Homo sapiens
[Reaction:R-HSA-6801250] TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane - Homo sapiens
[Reaction:R-HSA-6791302] TP53 binds the AIFM2 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-6791306] TP53 stimulates AIFM2 gene expression - Homo sapiens
[Reaction:R-HSA-6799418] TP53 binds the TP53INP1 gene - Homo sapiens
[BlackBoxEvent:R-HSA-6799416] TP53 stimulates expression of TP53INP1 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2016年06月27日
literatureReference
[LiteratureReference:3700985] Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
[LiteratureReference:6799772] ASPP proteins specifically stimulate the apoptotic function of p53
[LiteratureReference:6799791] ASPP1 and ASPP2: common activators of p53 family members
[LiteratureReference:140442] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53
[LiteratureReference:140387] Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
[LiteratureReference:6799802] ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo
[LiteratureReference:6800007] iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes
[LiteratureReference:140450] PUMA, a novel proapoptotic gene, is induced by p53
[LiteratureReference:6799790] Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax
[LiteratureReference:6791288] BID regulation by p53 contributes to chemosensitivity
[LiteratureReference:6798000] Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth
[LiteratureReference:6801169] The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase
[LiteratureReference:6801207] p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway
[LiteratureReference:6791300] AMID is a p53-inducible gene downregulated in tumors
[LiteratureReference:3215254] p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis
[LiteratureReference:3215228] TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
orthologousEvent
[Pathway:R-DME-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Drosophila melanogaster
[Pathway:R-PFA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Plasmodium falciparum
[Pathway:R-SCE-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Saccharomyces cerevisiae
[Pathway:R-SPO-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Schizosaccharomyces pombe
[Pathway:R-MMU-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Mus musculus
[Pathway:R-RNO-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Rattus norvegicus
[Pathway:R-CFA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Canis familiaris
[Pathway:R-BTA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Bos taurus
[Pathway:R-SSC-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Sus scrofa
[Pathway:R-GGA-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Gallus gallus
[Pathway:R-DDI-6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - Dictyostelium discoideum
releaseDate
2016年03月23日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855677] Zaccara, Sara, 2016年02月04日
[InstanceEdit:8855680] Inga, Alberto, 2016年02月04日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-6803204
summation
[Summation:6803210] Apoptotic transcriptional targets of TP53 include genes that...
updateTrackers
[UpdateTracker:9783222] Update Tracker - [Pathway:6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - v57:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes
(updatedInstance)
[UpdateTracker:9783222] Update Tracker - [Pathway:6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release - v57:[updateContainedRLE]
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