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TP53 Regulates Transcription of Cell Cycle Genes
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authored
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日
created
[InstanceEdit:6791313] Orlic-Milacic, Marija, 2015年08月20日
dbId
6791312
displayName
TP53 Regulates Transcription of Cell Cycle Genes
doi
10.3180/r-hsa-6791312.1
edited
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日
eventOf
[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53 - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:22659] DNA damage response, signal transduction by p53 class mediator
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest - Homo sapiens
[Pathway:R-HSA-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Homo sapiens
[Pathway:R-HSA-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2019年06月12日
literatureReference
[LiteratureReference:69405] WAF1, a potential mediator of p53 tumor suppression.
[LiteratureReference:69417] The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
[LiteratureReference:6803393] MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M
[LiteratureReference:6803408] The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability
[LiteratureReference:6798350] The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence
[LiteratureReference:6798297] E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression
[LiteratureReference:6791392] E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53
[LiteratureReference:6791380] Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage
[LiteratureReference:6791382] A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer
[LiteratureReference:6791366] A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence
[LiteratureReference:6791238] Gadd45a interacts with aurora-A and inhibits its kinase activity
[LiteratureReference:3215145] Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53
[LiteratureReference:6791112] Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase
[LiteratureReference:6791116] A novel role for Gadd45? in base excision repair: modulation of APE1 activity by the direct interaction of Gadd45? with PCNA
[LiteratureReference:6791110] Characterisation of the interaction between PCNA and Gadd45
[LiteratureReference:6791118] Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen
[LiteratureReference:6803862] 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression
[LiteratureReference:6803870] 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
[LiteratureReference:6803888] The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax
[LiteratureReference:6798286] DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter
[LiteratureReference:6798264] p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes
[LiteratureReference:6798034] Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway
[LiteratureReference:6798062] Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex
[LiteratureReference:6798041] The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene
[LiteratureReference:6798059] The BTG2 protein is a general activator of mRNA deadenylation
[LiteratureReference:6798058] Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
[LiteratureReference:6798055] The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex
[LiteratureReference:6798071] Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities
[LiteratureReference:6801634] Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells
[LiteratureReference:6801667] PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle
[LiteratureReference:6801678] Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication
[LiteratureReference:6801657] Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies
[LiteratureReference:5628898] Identification of novel p53 target genes in ionizing radiation response
[LiteratureReference:6802971] Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation
[LiteratureReference:6803912] RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest
[LiteratureReference:6803932] A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1
[LiteratureReference:6803952] hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer
[LiteratureReference:6803962] Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain
[LiteratureReference:6803710] Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation
[LiteratureReference:6801440] Transcriptional control of human p53-regulated genes
[LiteratureReference:6801441] A complex barcode underlies the heterogeneous response of p53 to stress
[LiteratureReference:6801433] Unravelling mechanisms of p53-mediated tumour suppression
[LiteratureReference:6801439] p53 in survival, death and metabolic health: a lifeguard with a licence to kill
maxDepth
3
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
TP53 Regulates Transcription of Cell Cycle Genes
orthologousEvent
[Pathway:R-DME-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Drosophila melanogaster
[Pathway:R-SCE-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Saccharomyces cerevisiae
[Pathway:R-MMU-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Mus musculus
[Pathway:R-PFA-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Plasmodium falciparum
[Pathway:R-SPO-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Schizosaccharomyces pombe
[Pathway:R-DDI-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Dictyostelium discoideum
[Pathway:R-CEL-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Caenorhabditis elegans
[Pathway:R-DRE-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Danio rerio
[Pathway:R-RNO-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Rattus norvegicus
[Pathway:R-GGA-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Gallus gallus
[Pathway:R-XTR-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Xenopus tropicalis
[Pathway:R-SSC-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Sus scrofa
[Pathway:R-BTA-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Bos taurus
[Pathway:R-CFA-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Canis familiaris
releaseDate
2016年03月23日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855677] Zaccara, Sara, 2016年02月04日
[InstanceEdit:8855680] Inga, Alberto, 2016年02月04日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-6791312
summation
[Summation:6804148] Under a variety of stress conditions, TP53 (p53), stabilized...
updateTrackers
[UpdateTracker:9780137] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v64:[updateIndirectRLE]
[UpdateTracker:9782033] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v60:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9777713] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v69:[updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53
(hasEncapsulatedEvent)
[Pathway:R-HSA-6804759] Regulation of TP53 Activity through Association with Co-factors
[Pathway:R-HSA-8853884] Transcriptional Regulation by VENTX
(updatedInstance)
[UpdateTracker:9780137] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v64:[updateIndirectRLE]
[UpdateTracker:9782033] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v60:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9777713] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v69:[updateIndirectRLE]
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