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Entries
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
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authored
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日
created
[InstanceEdit:6804113] Orlic-Milacic, Marija, 2015年10月08日
crossReference
[DatabaseIdentifier:12758032] BioModels Database:BIOMD0000000287
[DatabaseIdentifier:12757988] BioModels Database:BIOMD0000000939
[DatabaseIdentifier:12758100] BioModels Database:BIOMD0000000943
[DatabaseIdentifier:12758048] BioModels Database:BIOMD0000000700
[DatabaseIdentifier:12758054] BioModels Database:BIOMD0000000660
dbId
6804114
displayName
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
edited
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日
eventOf
[Pathway:R-HSA-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-3215152] TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter - Homo sapiens
[BlackBoxEvent:R-HSA-3215144] TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription - Homo sapiens
[Reaction:R-HSA-6791235] GADD45A binds AURKA - Homo sapiens
[Reaction:R-HSA-6791109] GADD45A binds PCNA - Homo sapiens
[Reaction:R-HSA-6798282] TP53 and E2F4 bind the CDC25C gene - Homo sapiens
[BlackBoxEvent:R-HSA-6798268] TP53 and E2F4 inhibit CDC25C expression - Homo sapiens
[Reaction:R-HSA-6803858] TP53 binds the SFN gene - Homo sapiens
[BlackBoxEvent:R-HSA-6803871] TP53 stimulates SFN expression - Homo sapiens
[Reaction:R-HSA-6803890] SFN dimerizes - Homo sapiens
[Reaction:R-HSA-6803875] SFN dimer binds CDK1 and CCNB1 - Homo sapiens
[Reaction:R-HSA-6803892] SFN dimer binds BAX - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:6791238] Gadd45a interacts with aurora-A and inhibits its kinase activity
[LiteratureReference:3215145] Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53
[LiteratureReference:6791112] Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase
[LiteratureReference:6791116] A novel role for Gadd45? in base excision repair: modulation of APE1 activity by the direct interaction of Gadd45? with PCNA
[LiteratureReference:6791110] Characterisation of the interaction between PCNA and Gadd45
[LiteratureReference:6791118] Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen
[LiteratureReference:6803862] 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression
[LiteratureReference:6803870] 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
[LiteratureReference:6803888] The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax
[LiteratureReference:6798286] DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter
[LiteratureReference:6798264] p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes
[LiteratureReference:6803710] Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
orthologousEvent
[Pathway:R-DME-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Drosophila melanogaster
[Pathway:R-PFA-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Plasmodium falciparum
[Pathway:R-CEL-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Caenorhabditis elegans
[Pathway:R-GGA-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Gallus gallus
[Pathway:R-XTR-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Xenopus tropicalis
[Pathway:R-DRE-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Danio rerio
[Pathway:R-SSC-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Sus scrofa
[Pathway:R-BTA-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Bos taurus
[Pathway:R-CFA-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Canis familiaris
[Pathway:R-RNO-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Rattus norvegicus
[Pathway:R-MMU-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Mus musculus
releaseDate
2016年03月23日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855677] Zaccara, Sara, 2016年02月04日
[InstanceEdit:8855680] Inga, Alberto, 2016年02月04日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-6804114
summation
[Summation:6804175] TP53 contributes to the establishment of G2 arrest by induci...
Referrals
(hasEvent)
[Pathway:R-HSA-6791312] TP53 Regulates Transcription of Cell Cycle Genes
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