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TP53 and E2F4 inhibit CDC25C expression Show undefined attributes

authored

[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日

category omitted

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:6798277] Orlic-Milacic, Marija, 2015年09月17日

dbId 6798268

displayName TP53 and E2F4 inhibit CDC25C expression

edited

[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015年10月14日

eventOf

[Pathway:R-HSA-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Homo sapiens

followingEvent

input

[EntityWithAccessionedSequence:R-HSA-6798280] CDC25C Gene [nucleoplasm]

isChimeric false

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

TP53 and E2F4 inhibit CDC25C expression

output

[EntityWithAccessionedSequence:R-HSA-69741] CDC25C [nucleoplasm]

precedingEvent

[Reaction:R-HSA-6798282] TP53 and E2F4 bind the CDC25C gene - Homo sapiens

regulatedBy

[NegativeGeneExpressionRegulation:R-HSA-6798285] Negative gene expression regulation by 'p-S15,S20-TP53 Tetramer:E2F4:(TFDP1,TFDP2):(RBL1,RBL2):CDC25C Gene [nucleoplasm]'

regulationReference

[RegulationReference:9642489] Negative gene expression regulation by 'p-S15,S20-TP53 Tetramer:E2F4:(TFDP1,TFDP2):(RBL1,RBL2):CDC25C Gene [nucleoplasm]' DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter

releaseDate 2016年03月23日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass BlackBoxEvent

species

[Species:48887] Homo sapiens

stId R-HSA-6798268

summation

[Summation:6798294] Binding of TP53 and the E2F4 repressor complex to the promot...

Referrals

(precedingEvent)

(hasEvent)

[Pathway:R-HSA-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

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