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Entries
Activation of Matrix Metalloproteinases
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authored
[InstanceEdit:1592294] Jupe, S, 2011年09月09日
created
[InstanceEdit:1592294] Jupe, S, 2011年09月09日
dbId
1592389
displayName
Activation of Matrix Metalloproteinases
edited
[InstanceEdit:2129374] Jupe, S, 2012年02月21日
eventOf
[Pathway:R-HSA-1474228] Degradation of the extracellular matrix - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:261789] extracellular matrix disassembly
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-1592316] Initial activation of proMMP1 - Homo sapiens
[Reaction:R-HSA-1602473] Autocatalytic activation of MMP1 - Homo sapiens
[Reaction:R-HSA-1592297] Full activation of MMP1 - Homo sapiens
[Reaction:R-HSA-1602454] proMMP9 binds TIMP1 - Homo sapiens
[Reaction:R-HSA-1592349] MMP14 (MT1-MMP) binds TIMP2 - Homo sapiens
[Reaction:R-HSA-1604350] MMP14:TIMP2 binds proMMP2 - Homo sapiens
[Reaction:R-HSA-1604359] Initial activation of proMMP2 by MMP1, 7 - Homo sapiens
[Reaction:R-HSA-1604360] Initial activation of proMMP2 by MMP14 - Homo sapiens
[Reaction:R-HSA-1592278] Autocatalytic activation of proMMP2 - Homo sapiens
[Reaction:R-HSA-1604368] Autocatalytic activation of bound proMMP2 - Homo sapiens
[Reaction:R-HSA-1592371] Initial activation of proMMP3 - Homo sapiens
[Reaction:R-HSA-1604731] Autocatalytic activation of MMP3 - Homo sapiens
[Reaction:R-HSA-1592362] Activation of proMMP7 by MMP3 - Homo sapiens
[Reaction:R-HSA-1604712] Initial activation of proMMP7 by trypsin - Homo sapiens
[Reaction:R-HSA-1604763] Autocatalytic activation of MMP7 - Homo sapiens
[BlackBoxEvent:R-HSA-1592398] Activation of proMMP8 - Homo sapiens
[Reaction:R-HSA-1592436] Initial activation of proMMP9 by MMPs - Homo sapiens
[Reaction:R-HSA-1604690] Activation of MMP9 intermediate form by MMPs - Homo sapiens
[Reaction:R-HSA-1604722] Activation of proMMP9 by proteases - Homo sapiens
[BlackBoxEvent:R-HSA-1602458] Activation of proMMP10 - Homo sapiens
[Reaction:R-HSA-1602484] Activation of proMMP11 by FURIN - Homo sapiens
[Reaction:R-HSA-1602488] Initial activation of proMMP13 by plasmin and trypsin - Homo sapiens
[Reaction:R-HSA-1604752] Initial activation of proMMP13 by MMP3 - Homo sapiens
[Reaction:R-HSA-1604741] Initial activation of proMMP13 by MMP14 (MT1-MMP) - Homo sapiens
[Reaction:R-HSA-1604732] Autocatalytic activation of proMMP13 - Homo sapiens
[Reaction:R-HSA-1602466] Activation of MT-MMPs by FURIN - Homo sapiens
[BlackBoxEvent:R-HSA-1605825] MT-MMPs are sorted to the plasma membrane - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2016年06月27日
literatureReference
[Book:1474202] Matrix Metalloproteinases and TIMPs Woessner, J 0 19 850268 0
[LiteratureReference:2157512] The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases
[LiteratureReference:2157522] Updated biological roles for matrix metalloproteinases and new "intracellular" substrates revealed by degradomics
[LiteratureReference:2157525] Matrix metalloproteinase proteomics: substrates, targets, and therapy
[LiteratureReference:2157477] Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics
maxDepth
2
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Activation of Matrix Metalloproteinases
orthologousEvent
[Pathway:R-MMU-1592389] Activation of Matrix Metalloproteinases - Mus musculus
[Pathway:R-RNO-1592389] Activation of Matrix Metalloproteinases - Rattus norvegicus
[Pathway:R-CFA-1592389] Activation of Matrix Metalloproteinases - Canis familiaris
[Pathway:R-BTA-1592389] Activation of Matrix Metalloproteinases - Bos taurus
[Pathway:R-SSC-1592389] Activation of Matrix Metalloproteinases - Sus scrofa
[Pathway:R-DRE-1592389] Activation of Matrix Metalloproteinases - Danio rerio
[Pathway:R-XTR-1592389] Activation of Matrix Metalloproteinases - Xenopus tropicalis
[Pathway:R-GGA-1592389] Activation of Matrix Metalloproteinases - Gallus gallus
[Pathway:R-DME-1592389] Activation of Matrix Metalloproteinases - Drosophila melanogaster
[Pathway:R-CEL-1592389] Activation of Matrix Metalloproteinases - Caenorhabditis elegans
releaseDate
2012年03月13日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2157481] Butler, GS, 2012年02月28日
[InstanceEdit:2157511] Overall, CM, 2012年02月28日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1592389
summation
[Summation:1604781] The matrix metalloproteinases (MMPs), previously known as ma...
updateTrackers
[UpdateTracker:9788414] Update Tracker - [Pathway:1592389] Activation of Matrix Metalloproteinases - v42:[modifyText]
[UpdateTracker:9783269] Update Tracker - [Pathway:1592389] Activation of Matrix Metalloproteinases - v57:[updateContainedRLE]
[UpdateTracker:9788157] Update Tracker - [Pathway:1592389] Activation of Matrix Metalloproteinases - v43:[updateContainedRLE]
[UpdateTracker:9788543] Update Tracker - [Pathway:1592389] Activation of Matrix Metalloproteinases - v41:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-1474228] Degradation of the extracellular matrix
(hasEncapsulatedEvent)
[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(updatedInstance)
[UpdateTracker:9788414] Update Tracker - [Pathway:1592389] Activation of Matrix Metalloproteinases - v42:[modifyText]
[UpdateTracker:9783269] Update Tracker - [Pathway:1592389] Activation of Matrix Metalloproteinases - v57:[updateContainedRLE]
[UpdateTracker:9788157] Update Tracker - [Pathway:1592389] Activation of Matrix Metalloproteinases - v43:[updateContainedRLE]
[UpdateTracker:9788543] Update Tracker - [Pathway:1592389] Activation of Matrix Metalloproteinases - v41:[updateContainedRLE]
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