Reactome Pathway Database

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MMP14:TIMP2 binds proMMP2 Show undefined attributes

authored

[InstanceEdit:1592294] Jupe, S, 2011年09月09日

category binding

compartment

created [InstanceEdit:1604374] Jupe, S, 2011年09月15日

dbId 1604350

displayName MMP14:TIMP2 binds proMMP2

edited

[InstanceEdit:2129374] Jupe, S, 2012年02月21日

eventOf

[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases - Homo sapiens

followingEvent

[Reaction:R-HSA-1604360] Initial activation of proMMP2 by MMP14 - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

MMP14:TIMP2 binds proMMP2

orthologousEvent

output

[Complex:R-HSA-1604369] MMP14:TIMP2:proMMP2 [plasma membrane]

precedingEvent

[Reaction:R-HSA-1592349] MMP14 (MT1-MMP) binds TIMP2 - Homo sapiens

releaseDate 2012年03月13日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-1604350

summation

[Summation:1604344] The MMP14:TIMP2 complex can efficiently bind proMMP2. Physio...

Referrals

(hasEvent)

[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases

(precedingEvent)

[Reaction:R-HSA-1604360] Initial activation of proMMP2 by MMP14

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