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Autocatalytic activation of proMMP13 Show undefined attributes

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authored

[InstanceEdit:1592294] Jupe, S, 2011年09月09日

catalystActivity

[CatalystActivity:1604716] serine-type endopeptidase activity of MMP13 intermediate forms [extracellular region]

category transition

compartment

[Compartment:984] extracellular region

created [InstanceEdit:1604747] Jupe, S, 2011年09月19日

dbId 1604732

displayName Autocatalytic activation of proMMP13

edited

[InstanceEdit:2129374] Jupe, S, 2012年02月21日

eventOf

[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases - Homo sapiens

input

[DefinedSet:R-HSA-1604714] MMP13 intermediate forms [extracellular region]

isChimeric false

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

Autocatalytic activation of proMMP13

orthologousEvent

output

precedingEvent

regulatedBy

[NegativeRegulation:R-HSA-2225577] Negative regulation by 'COL18A1(1572-11754) [extracellular region]'

regulationReference

[RegulationReference:9642680] Negative regulation by 'COL18A1(1572-11754) [extracellular region]' Endostatin inhibits human tongue carcinoma cell invasion and intravasation and blocks the activation of matrix metalloprotease-2, -9, and -13

releaseDate 2012年03月13日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-1604732

summation

[Summation:1604740] Following initial activation autoproteolysis occurs at Glu10...

updateTrackers

[UpdateTracker:9788572] Update Tracker - [Reaction:1604732] Autocatalytic activation of proMMP13 - v41:[addRegulator, modifyText]

Referrals

(updatedInstance)

[UpdateTracker:9788572] Update Tracker - [Reaction:1604732] Autocatalytic activation of proMMP13 - v41:[addRegulator, modifyText]

(hasEvent)

[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases

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