Reactome Pathway Database

Schema > Reaction > Entries

Initial activation of proMMP13 by MMP3 Show undefined attributes

authored

[InstanceEdit:1592294] Jupe, S, 2011年09月09日

catalystActivity

[CatalystActivity:1604695] serine-type endopeptidase activity of MMP3, CTSK, CTSL2 [extracellular region]

category transition

compartment

[Compartment:984] extracellular region

created [InstanceEdit:1604747] Jupe, S, 2011年09月19日

dbId 1604752

displayName Initial activation of proMMP13 by MMP3

edited

[InstanceEdit:2129374] Jupe, S, 2012年02月21日

eventOf

[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases - Homo sapiens

followingEvent

[Reaction:R-HSA-1604732] Autocatalytic activation of proMMP13 - Homo sapiens

input

[EntityWithAccessionedSequence:R-HSA-1604702] MMP13(20-471) [extracellular region]

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:1458404] Biochemical characterization of human collagenase-3

maxDepth 1

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

Initial activation of proMMP13 by MMP3

orthologousEvent

output

releaseDate 2012年03月13日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-1604752

summation

[Summation:1604744] MMP3 initially cleaves proMMP13 at Gly76-Leu77 followed by a...

Referrals

(hasEvent)

[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases

(precedingEvent)

[Reaction:R-HSA-1604732] Autocatalytic activation of proMMP13

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