SPTBN5

Protein-coding gene in the species Homo sapiens

SPTBN5

Identifiers

SPTBN5 , BSPECV, HUBSPECV, HUSPECV, spectrin beta, non-erythrocytic 5

External IDs

OMIM: 605916; MGI: 2685200; HomoloGene: 41150; GeneCards: SPTBN5; OMA:SPTBN5 - orthologs

Gene location (Human)
Chromosome 15 (human)
Chr.	Chromosome 15 (human) ^[1]
Chromosome 15 (human) Genomic location for SPTBN5 Genomic location for SPTBN5
Band	15q15.1	Start	41,848,146 bp ^[1]
Band	15q15.1	End	41,894,053 bp ^[1]

Gene location (Mouse)
Chromosome 2 (mouse)
Chr.	Chromosome 2 (mouse)^[2]
Chromosome 2 (mouse) Genomic location for SPTBN5 Genomic location for SPTBN5
Band	2\|2 E5	Start	119,871,974 bp ^[2]
Band	2\|2 E5	End	119,916,159 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in sural nerve cerebellar hemisphere right hemisphere of cerebellum testicle apex of heart retinal pigment epithelium skin of abdomen granulocyte left ventricle right lobe of thyroid gland	Top expressed in esophagus muscle of thigh Hypothalamus muscle tissue skeletal muscle tissue quadriceps femoris muscle lip striatum of neuraxis zone of skin islet of Langerhans
More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	dynactin binding protein self-association kinesin binding myosin tail binding actin binding dynein intermediate chain binding spectrin binding
Cellular component	cytoplasm cytosol spectrin membrane photoreceptor connecting cilium photoreceptor disc membrane cytoskeleton microtubule organizing center filamentous actin
Biological process	Golgi organization MAPK cascade axon guidance endoplasmic reticulum to Golgi vesicle-mediated transport actin filament capping lysosomal transport protein homooligomerization actin cytoskeleton organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51332


640524

Ensembl


ENSG00000137877


ENSMUSG00000074899

UniProt


Q9NRC6


n/a

RefSeq (mRNA)

NM_016642

NM_001370938

RefSeq (protein)

NP_057726

n/a

Location (UCSC)

Chr 15: 41.85 – 41.89 Mb

Chr 2: 119.87 – 119.92 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Spectrin, beta, non-erythrocytic 5 also known as SPTBN5 is a protein that in humans is encoded by the SPTBN5 gene.^[5] SPTBN5 belongs to the spectrin family of cytoskeletal proteins.

Structure and function

[edit ]

SPTBN5 contains the following domains:^[5]

actin-binding domain
membrane-association domain-1
self-association domain
C-terminal pleckstrin homology domain.

Based on these structural features it is thought that SPTBN5 is likely to form heterodimers and oligomers with alpha-spectrin and to interact directly with cellular membranes.^[5]

SPTBN5 is highly expressed in embryoid bodies.^[6]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137877 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074899 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Stabach PR, Morrow JS (July 2000). "Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin". J. Biol. Chem. 275 (28): 21385–95. doi:10.1074/jbc.C000159200 . PMID 10764729.
^ Chaerkady R, Kerr CL, Marimuthu A, Kelkar DS, Kashyap MK, Gucek M, Gearhart JD, Pandey A (January 2009). "Temporal analysis of neural differentiation using quantitative proteomics". J. Proteome Res. 8 (3): 1315–26. doi:10.1021/pr8006667. PMC 2693473 . PMID 19173612.

Odell AF, Van Helden DF, Scott JL (2008). "The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels". J. Biol. Chem. 283 (7): 4395–407. doi:10.1074/jbc.M709729200 . hdl:1959.13/39937 . PMID 18048348.
Oguri M, Kato K, Yokoi K, et al. (2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190 . PMID 19851296.
Shoeman RL, Hartig R, Hauses C, Traub P (2002). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease". Cell Biol. Int. 26 (6): 529–39. doi:10.1006/cbir.2002.0895. PMID 12119179. S2CID 39778155.
Chardin P, Camonis JH, Gale NW, et al. (1993). "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2". Science. 260 (5112): 1338–43. Bibcode:1993Sci...260.1338C. doi:10.1126/science.8493579. PMID 8493579.

v
t
e

Proteins of the cytoskeleton

Human

Microfilaments
and ABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
and MAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal: DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3