TUBG2

Protein-coding gene in the species Homo sapiens

TUBG2

Identifiers

TUBG2 , tubulin gamma 2

External IDs

OMIM: 605785; MGI: 2144208; HomoloGene: 69216; GeneCards: TUBG2; OMA:TUBG2 - orthologs

Gene location (Human)
Chromosome 17 (human)
Chr.	Chromosome 17 (human) ^[1]
Chromosome 17 (human) Genomic location for TUBG2 Genomic location for TUBG2
Band	17q21.2	Start	42,659,284 bp ^[1]
Band	17q21.2	End	42,667,006 bp ^[1]

Gene location (Mouse)
Chromosome 11 (mouse)
Chr.	Chromosome 11 (mouse)^[2]
Chromosome 11 (mouse) Genomic location for TUBG2 Genomic location for TUBG2
Band	11\|11 D	Start	101,046,733 bp ^[2]
Band	11\|11 D	End	101,052,613 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in right frontal lobe right hemisphere of cerebellum anterior cingulate cortex prefrontal cortex body of pancreas Amygdala Brodmann area 9 C1 segment nucleus accumbens caudate nucleus	Top expressed in zygote secondary oocyte primary oocyte incisor superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex dorsomedial hypothalamic nucleus superior colliculus neural layer of retina
More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	nucleotide binding GTP binding structural molecule activity GTPase activity structural constituent of cytoskeleton
Cellular component	cytoplasm microtubule cytoskeleton microtubule organizing center cytoplasmic microtubule cytosol centrosome spindle microtubule gamma-tubulin complex pericentriolar material cytoskeleton microtubule nucleus spindle
Biological process	cytoplasmic microtubule organization microtubule nucleation microtubule-based process mitotic sister chromatid segregation meiotic spindle organization microtubule cytoskeleton organization mitotic cell cycle mitotic spindle organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


27175


103768

Ensembl


ENSG00000037042


ENSMUSG00000045007

UniProt


Q9NRH3


Q8VCK3

RefSeq (mRNA)

NM_016437
NM_001320509

NM_134028

RefSeq (protein)

NP_001307438
NP_057521

NP_598789

Location (UCSC)

Chr 17: 42.66 – 42.67 Mb

Chr 11: 101.05 – 101.05 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene.^[5]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000037042 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045007 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TUBG2 tubulin, gamma 2".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Tassin AM, Celati C, Moudjou M, Bornens M (1998). "Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin". J. Cell Biol. 141 (3): 689–701. doi:10.1083/jcb.141.3.689. PMC 2132749 . PMID 9566969.
Herreros L, Rodríguez-Fernandez JL, Brown MC, et al. (2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton". J. Biol. Chem. 275 (34): 26436–40. doi:10.1074/jbc.M003970200 . hdl:10261/135387 . PMID 10840040.
Wise DO, Krahe R, Oakley BR (2000). "The gamma-tubulin gene family in humans". Genomics. 67 (2): 164–70. doi:10.1006/geno.2000.6247. PMID 10903841.
Niwa J, Ishigaki S, Doyu M, et al. (2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem. Biophys. Res. Commun. 281 (3): 706–13. doi:10.1006/bbrc.2001.4414. PMID 11237715.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285 . PMID 14702039.
Chang F, Re F, Sebastian S, et al. (2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes". Mol. Biol. Cell. 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMC 379276 . PMID 14767062.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

v t e PDB gallery
1z5v: Crystal structure of human gamma-tubulin bound to GTPgammaS 1z5v: Crystal structure of human gamma-tubulin bound to GTPgammaS 1z5w: Crystal Structure of gamma-tubulin bound to GTP 1z5w: Crystal Structure of gamma-tubulin bound to GTP

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References

Further reading