TUBGCP4

Protein-coding gene in the species Homo sapiens

TUBGCP4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3RIP

Identifiers

Aliases

TUBGCP4 , 76P, GCP-4, GCP4, Grip76, MCCRP3, tubulin gamma complex associated protein 4

External IDs

OMIM: 609610; MGI: 1196293; HomoloGene: 8690; GeneCards: TUBGCP4; OMA:TUBGCP4 - orthologs

Gene location (Human)
Chromosome 15 (human)
Chr.	Chromosome 15 (human) ^[1]
Chromosome 15 (human) Genomic location for TUBGCP4 Genomic location for TUBGCP4
Band	15q15.3	Start	43,369,221 bp ^[1]
Band	15q15.3	End	43,409,771 bp ^[1]

Gene location (Mouse)
Chromosome 2 (mouse)
Chr.	Chromosome 2 (mouse)^[2]
Chromosome 2 (mouse) Genomic location for TUBGCP4 Genomic location for TUBGCP4
Band	2 E5\|2 60.37 cM	Start	121,001,135 bp ^[2]
Band	2 E5\|2 60.37 cM	End	121,029,251 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in sperm secondary oocyte buccal mucosa cell ganglionic eminence ventricular zone gonad testicle tibialis anterior muscle epithelium of colon cerebellar hemisphere	Top expressed in ascending aorta spermatocyte tail of embryo genital tubercle aortic valve supraoptic nucleus neural layer of retina internal carotid artery thymus spermatid
More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	structural constituent of cytoskeleton microtubule minus-end binding protein binding gamma-tubulin binding
Cellular component	cytoplasm microtubule organizing center gamma-tubulin complex cytosol spindle pole body spindle pole recycling endosome equatorial microtubule organizing center membrane microtubule microtubule cytoskeleton cytoskeleton centrosome
Biological process	microtubule nucleation by interphase microtubule organizing center microtubule cytoskeleton organization mitotic spindle assembly centrosome duplication cytoplasmic microtubule organization microtubule nucleation meiosis mitotic cell cycle spindle assembly protein-containing complex assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


27229


51885

Ensembl


ENSG00000137822


ENSMUSG00000027263

UniProt


Q9UGJ1


Q9D4F8

RefSeq (mRNA)

NM_001286414
NM_014444

NM_001290824
NM_153387

RefSeq (protein)

NP_001273343
NP_055259

NP_001277753
NP_700436

Location (UCSC)

Chr 15: 43.37 – 43.41 Mb

Chr 2: 121 – 121.03 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene.^[5] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137822 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027263 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Tubulin, gamma complex associated protein 4".

Hsu HL, Yeh NH (February 1996). "Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis". Journal of Cell Science. 109 ( Pt 2) (2): 277–88. doi:10.1242/jcs.109.2.277. PMID 8838651.
Haren L, Merdes A (May 2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules". Journal of Cell Science. 115 (Pt 9): 1815–24. doi:10.1242/jcs.115.9.1815. PMID 11956313.
Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (November 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Molecular Biology of the Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259 . PMID 11694571.
Fava F, Raynaud-Messina B, Leung-Tack J, Mazzolini L, Li M, Guillemot JC, Cachot D, Tollon Y, Ferrara P, Wright M (November 1999). "Human 76p: A new member of the gamma-tubulin-associated protein family". The Journal of Cell Biology. 147 (4): 857–68. doi:10.1083/jcb.147.4.857. PMC 2156165 . PMID 10562286.
Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (September 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Molecular Biology of the Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155 . PMID 12221128.

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TUBGCP4

See also

References

Further reading