DNAH9

Protein-coding gene in the species Homo sapiens

DNAH9

Identifiers

DNAH9 , DNAH17L, DNEL1, DYH9, Dnahc9, HL-20, HL20, dynein axonemal heavy chain 9, CILD40

External IDs

OMIM: 603330; MGI: 1289279; HomoloGene: 20357; GeneCards: DNAH9; OMA:DNAH9 - orthologs

Gene location (Human)
Chromosome 17 (human)
Chr.	Chromosome 17 (human) ^[1]
Chromosome 17 (human) Genomic location for DNAH9 Genomic location for DNAH9
Band	17p12	Start	11,598,470 bp ^[1]
Band	17p12	End	11,969,748 bp ^[1]

Gene location (Mouse)
Chromosome 11 (mouse)
Chr.	Chromosome 11 (mouse)^[2]
Chromosome 11 (mouse) Genomic location for DNAH9 Genomic location for DNAH9
Band	11 B3\|11 40.53 cM	Start	65,722,108 bp ^[2]
Band	11 B3\|11 40.53 cM	End	66,059,377 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in right uterine tube bronchial epithelial cell olfactory zone of nasal mucosa mucosa of paranasal sinus epithelium of nasopharynx C1 segment sperm testicle caudate nucleus secondary oocyte	Top expressed in choroidal fissure zygote secondary oocyte choroid plexus of fourth ventricle olfactory epithelium primary oocyte Epithelium of choroid plexus embryo neural layer of retina dentate gyrus of hippocampal formation granule cell
More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	microtubule motor activity nucleotide binding ATPase activity ATP binding cytoskeletal motor activity minus-end-directed microtubule motor activity dynein light chain binding dynein intermediate chain binding dynein light intermediate chain binding
Cellular component	cytoplasm axoneme cell projection cilium microtubule cytoskeleton dynein complex motile cilium 9+2 motile cilium distal portion of axoneme
Biological process	microtubule-based movement cell projection organization cilium movement
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1770


237806

Ensembl


ENSG00000007174


ENSMUSG00000056752

UniProt


Q9NYC9


n/a

RefSeq (mRNA)

NM_001372
NM_004662

NM_001099633

RefSeq (protein)

NP_001363
NP_004653

n/a

Location (UCSC)

Chr 17: 11.6 – 11.97 Mb

Chr 11: 65.72 – 66.06 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Dynein heavy chain 9, axonemal is a protein that in humans is encoded by the DNAH9 gene.^[5]^[6]^[7]

This gene encodes the heavy chain subunit of axonemal dynein, a large multi-subunit molecular motor. Axonemal dynein attaches to microtubules and hydrolyzes ATP to mediate the movement of cilia and flagella. The gene expresses at least two transcript variants; additional variants have been described, but their full length nature has not been determined.^[7]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007174 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056752 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (Feb 1997). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.
^ Bartoloni L, Blouin JL, Maiti AK, Sainsbury A, Rossier C, Gehrig C, She JX, Marron MP, Lander ES, Meeks M, Chung E, Armengot M, Jorissen M, Scott HS, Delozier-Blanchet CD, Gardiner RM, Antonarakis SE (Mar 2001). "Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia". Genomics. 72 (1): 21–33. doi:10.1006/geno.2000.6462. hdl:2123/16163 . PMID 11247663.
^ ^a ^b "Entrez Gene: DNAH9 dynein, axonemal, heavy chain 9".

Milisav I, Jones MH, Affara NA (1996). "Characterization of a novel human dynein-related gene that is specifically expressed in testis". Mamm. Genome. 7 (9): 667–72. doi:10.1007/s003359900202. PMID 8703119. S2CID 30004271.
Nagase T; Ishikawa K; Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141 . PMID 9205841.
Bartoloni L; Blouin J; Sainsbury AJ; et al. (1999). "Assignment of the human dynein heavy chain gene DNAH17L to human chromosome 17p12 by in situ hybridization and radiation hybrid mapping". Cytogenet. Cell Genet. 84 (3–4): 188–9. doi:10.1159/000015254. PMID 10393427. S2CID 1495548.
Reed W; Carson JL; Moats-Staats BM; et al. (2001). "Characterization of an axonemal dynein heavy chain expressed early in airway epithelial ciliogenesis". Am. J. Respir. Cell Mol. Biol. 23 (6): 734–41. CiteSeerX 10.1.1.321.874 . doi:10.1165/ajrcmb.23.6.4045. PMID 11104725.
Maiti AK; Mattéi MG; Jorissen M; et al. (2001). "Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes". Eur. J. Hum. Genet. 8 (12): 923–32. doi:10.1038/sj.ejhg.5200555 . PMID 11175280.
Carson JL; Reed W; Lucier T; et al. (2002). "Axonemal dynein expression in human fetal tracheal epithelium". Am. J. Physiol. Lung Cell Mol. Physiol. 282 (3): L421–30. doi:10.1152/ajplung.00147.2001. PMID 11839535. S2CID 23922796.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285 . PMID 14702039.
Horváth J; Fliegauf M; Olbrich H; et al. (2005). "Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients". Am. J. Respir. Cell Mol. Biol. 33 (1): 41–7. doi:10.1165/rcmb.2004-0335OC. PMID 15845866. S2CID 19776274.

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References

Further reading