DYNC1LI2

Protein-coding gene in the species Homo sapiens

DYNC1LI2

Identifiers

DYNC1LI2 , DNCLI2, LIC2, dynein cytoplasmic 1 light intermediate chain 2

External IDs

OMIM: 611406; MGI: 107738; HomoloGene: 4474; GeneCards: DYNC1LI2; OMA:DYNC1LI2 - orthologs

Gene location (Human)
Chromosome 16 (human)
Chr.	Chromosome 16 (human) ^[1]
Chromosome 16 (human) Genomic location for DYNC1LI2 Genomic location for DYNC1LI2
Band	16q22.1	Start	66,720,893 bp ^[1]
Band	16q22.1	End	66,751,609 bp ^[1]

Gene location (Mouse)
Chromosome 8 (mouse)
Chr.	Chromosome 8 (mouse)^[2]
Chromosome 8 (mouse) Genomic location for DYNC1LI2 Genomic location for DYNC1LI2
Band	8 D3\|8 53.04 cM	Start	105,144,312 bp ^[2]
Band	8 D3\|8 53.04 cM	End	105,169,679 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in endothelial cell inferior ganglion of vagus nerve pars reticulata subthalamic nucleus external globus pallidus internal globus pallidus pars compacta Brodmann area 23 superior vestibular nucleus Pons	Top expressed in central gray substance of midbrain hand neural layer of retina globus pallidus superior frontal gyrus cerebellar cortex deep cerebellar nuclei inferior colliculi medial geniculate nucleus pontine nuclei
More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	microtubule motor activity nucleotide binding cytoskeletal motor activity ATP binding dynein heavy chain binding
Cellular component	cytoplasm cytosol membrane dynein complex microtubule cytoskeleton cytoplasmic dynein complex kinetochore lysosome late endosome centrosome
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II centrosome localization endoplasmic reticulum to Golgi vesicle-mediated transport microtubule cytoskeleton organization microtubule-based movement sister chromatid cohesion transport protein homooligomerization cellular response to nerve growth factor stimulus
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1783


234663

Ensembl


ENSG00000135720


ENSMUSG00000035770

UniProt


O43237


Q6PDL0

RefSeq (mRNA)

NM_001286157
NM_006141
NM_001323955

NM_001013380

RefSeq (protein)

NP_001273086
NP_001310884
NP_006132
NP_006132.1

NP_001013398

Location (UCSC)

Chr 16: 66.72 – 66.75 Mb

Chr 8: 105.14 – 105.17 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Cytoplasmic dynein 1 light intermediate chain 2 is a protein that in humans is encoded by the DYNC1LI2 gene.^[5]^[6]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135720 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035770 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247 . PMID 16260502.
^ "Entrez Gene: DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2".

Hughes SM, Vaughan KT, Herskovits JS, Vallee RB (1995). "Molecular analysis of a cytoplasmic dynein light intermediate chain reveals homology to a family of ATPases". J. Cell Sci. 108 (1): 17–24. doi:10.1242/jcs.108.1.17. PMID 7738094.
Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590 . PMID 12417987.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285 . PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006年09月02日6 . PMID 17081983. S2CID 7827573.

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References

Further reading