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Mondo:0005109 Show undefined attributes

databaseName Mondo

dbId 11944912

displayName Mondo:0005109

identifier 0005109

referenceDatabase [ReferenceDatabase:11944889] Mondo

schemaClass DatabaseIdentifier

url https://monarchinitiative.org/MONDO:0005109

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[Reaction:R-HSA-175177] Association of XRCC4:DNA ligase IV complex with viral DNA ends
[Complex:R-HSA-3244619] TREX1:viral DNA [endoplasmic reticulum membrane]
[ChemicalDrug:R-ALL-2162091] carbovir triphosphate [cytosol]
[Polymer:R-HIV-165542] Rev-multimer [nucleoplasm]
[GenomeEncodedEntity:R-HIV-9684900] HIV1 GU-rich ssRNA [endosome lumen]
[Polymer:R-HIV-175314] Multimeric capsid coat [cytosol]
[Polymer:R-HIV-165543] Rev-multimer [cytosol]
[ChemicalDrug:R-ALL-9732844] nelfinavir [cytosol]
[ChemicalDrug:R-ALL-2161185] abacavir [cytosol]
[ChemicalDrug:R-ALL-9731577] raltegravir [cytosol]
[ChemicalDrug:R-ALL-2162075] carbovir diphosphate [cytosol]
[ChemicalDrug:R-ALL-9679059] troleandomycin [cytosol]
[ChemicalDrug:R-ALL-9714412] nefazodone [extracellular region]
[ChemicalDrug:R-ALL-9681086] cobicistat [cytosol]
[ChemicalDrug:R-ALL-9696601] darunavir [extracellular region]
[ProteinDrug:R-ALL-9680829] His-Leu-lopinavir [extracellular region]
[ChemicalDrug:R-ALL-2161514] carbovir [cytosol]
[ChemicalDrug:R-ALL-9679091] ritonavir [cytosol]
[ChemicalDrug:R-ALL-9681011] tenofovir [cytosol]
[Complex:R-HSA-9835916] tat72:EIF2AK2 [cytosol]
[EntityWithAccessionedSequence:R-HIV-9835890] tat72 [cytosol]
[DefinedSet:R-NUL-9684903] GU-rich ssRNA [endosome lumen]
[ChemicalDrug:R-ALL-9678909] ketoconazole [cytosol]
[ChemicalDrug:R-ALL-2161194] abacavir monophosphate [cytosol]
[ChemicalDrug:R-ALL-2161176] carbovir monophosphate [cytosol]
[ChemicalDrug:R-ALL-2161525] abacavir [extracellular region]
[ChemicalDrug:R-ALL-9678801] nefazodone [cytosol]
[GenomeEncodedEntity:R-HIV-9842175] HIV TAR RNA [cytosol]
[EntityWithAccessionedSequence:R-HIV-171211] Surface protein gp120 [viral envelope]
[ChemicalDrug:R-ALL-9681031] emtricitabine [cytosol]
[DefinedSet:R-NUL-9684904] TLR7, TLR8 ligands [endosome lumen]
[Reaction:R-HSA-180630] Association of APOBEC3G with Gag
[Pathway:R-HSA-180897] Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
[Reaction:R-HSA-9836449] p-PKR dimer phosphorylates HIV tat
[Reaction:R-HSA-165028] Release of the HIV mRNA and Crm1 from Rev in the cytoplasm
[Reaction:R-HSA-180622] Vpr binds nucleoporins
[Reaction:R-HSA-167288] TFIIS-mediated recovery of HIV-1 elongation from arrest
[Reaction:R-HSA-9839025] HIV TAR RNA binds PKR
[Pathway:R-HSA-167242] Abortive elongation of HIV-1 transcript in the absence of Tat
[Reaction:R-HSA-180732] Translocation of Rev:importin-beta:B23 to the nucleus
[Reaction:R-HSA-180606] Association of Vpu with CD4
[BlackBoxEvent:R-HSA-9708408] DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid
[Reaction:R-HSA-167234] Association of Tat with P-TEFb(Cyclin T1:Cdk9)
[Pathway:R-HSA-167169] HIV Transcription Elongation
[Reaction:R-HSA-165033] Multimerization of Rev
[Reaction:R-HSA-167478] Abortive termination of HIV-1 early transcription elongation by DSIF:NELF
[Pathway:R-HSA-167158] Formation of the HIV-1 Early Elongation Complex
[Reaction:R-HSA-180885] Rev multimer-bound HIV mRNA associates with Crm1
[Reaction:R-HSA-167085] Formation of DSIF:NELF:HIV-1 early elongation complex
[Reaction:R-HSA-167134] Newly formed phosphodiester bond stabilized and PPi released
[Reaction:R-HSA-167284] 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
[Reaction:R-HSA-180709] Association of multimerized Rev with beta-importin
[Reaction:R-HSA-167474] Abortive HIV-1 Initiation Before Second Transition
[Reaction:R-HSA-167118] NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex
[Reaction:R-HSA-165047] Translocation of nuclear RNA transport complex to cytoplasm
[Reaction:R-HSA-167196] Recruitment of elongation factors to form HIV-1 elongation complex
[Reaction:R-HSA-167481] Abortive termination of HIV-1 elongation after arrest
[Reaction:R-HSA-167083] DSIF complex binds to RNA Pol II (hypophosphorylated)
[BlackBoxEvent:R-HSA-167121] Addition of the third nucleotide on the nascent HIV-1 transcript
[Reaction:R-HSA-167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
[Reaction:R-HSA-180728] Association of Ran-GTP with importin-beta
[Reaction:R-HSA-167089] Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex
[Pathway:R-HSA-167200] Formation of HIV-1 elongation complex containing HIV-1 Tat
[BlackBoxEvent:R-HSA-9613498] Unwinding of DNA for the nascent HIV-1 transcript
[Reaction:R-HSA-170704] Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex
[Reaction:R-HSA-180725] Rev associates with B23
[Reaction:R-HSA-180905] Association of Vpr with ANT1
[Pathway:R-HSA-165054] Rev-mediated nuclear export of HIV RNA
[Reaction:R-HSA-167197] Separation of elongating HIV-1 transcript from template
[Reaction:R-HSA-167072] Hypophosphorylation of RNA Pol II CTD by FCP1P protein
[Pathway:R-HSA-180746] Nuclear import of Rev protein
[Pathway:R-HSA-180910] Vpr-mediated nuclear import of PICs
[Reaction:R-HSA-167136] Addition of nucleotides 5 through 9 on the growing HIV-1 transcript
[Pathway:R-HSA-167246] Tat-mediated elongation of the HIV-1 transcript
[Reaction:R-HSA-180855] Translocation of Vpr to the mitochondria
[Reaction:R-HSA-167150] Resumption of elongation of HIV-1 transcript after recovery from pausing
[Reaction:R-HSA-167130] Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP
[Reaction:R-HSA-165043] Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC
[Pathway:R-HSA-180534] Vpu mediated degradation of CD4
[BlackBoxEvent:R-HSA-180573] Degradation of ubiquitinated CD4
[Pathway:R-HSA-176033] Interactions of Vpr with host cellular proteins
[Reaction:R-HSA-165055] Hydrolysis of Ran:GTP to Ran:GDP
[Pathway:R-HSA-167152] Formation of HIV elongation complex in the absence of HIV Tat
[Pathway:R-HSA-180689] APOBEC3G mediated resistance to HIV-1 infection
[Reaction:R-HSA-167087] Limited elongation of the HIV-1 transcript
[Reaction:R-HSA-180597] Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex
[Reaction:R-HSA-180710] Rev:importin beta:B23 recruited to the nuclear pore
[Reaction:R-HSA-167147] Separation of abortive HIV-1 transcript from template
[Reaction:R-HSA-167191] Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex
[BlackBoxEvent:R-HSA-167113] Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition
[Reaction:R-HSA-180634] Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand
[BlackBoxEvent:R-HSA-9613490] Unwinding of DNA for the nascent HIV-1 transcript: Second Transition
[Reaction:R-HSA-167076] 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
[Reaction:R-HSA-180599] The Vpu:CD4:beta-TrCP complex recruits SKP1
[Reaction:R-HSA-9835949] HIV Tat72 binds PKR
[Reaction:R-HSA-167192] Pol II elongation complex moves on the HIV-1 template as transcript elongates
[Reaction:R-HSA-180591] Vpu:CD4 associates with beta-TrCP
[Reaction:R-HSA-167181] Addition of nucleotides leads to HIV-1 transcript elongation
[Reaction:R-HSA-180736] Disassembly of the Rev-importin beta-B23:Ran-GTP complex
[Reaction:R-HSA-180632] Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand
[Reaction:R-HSA-170706] Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
[Pathway:R-HSA-167238] Pausing and recovery of Tat-mediated HIV elongation
[Reaction:R-HSA-167097] HIV Promoter Opening: First Transition
[Reaction:R-HSA-180739] Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex
[Pathway:R-HSA-167287] HIV elongation arrest and recovery
[Reaction:R-HSA-167235] Formation of the P-TEFb(Cyclin T1:Cdk9) complex
[Pathway:R-HSA-176034] Interactions of Tat with host cellular proteins
[Reaction:R-HSA-165034] Rev multimer-bound HIV mRNA:CRM1 complex associates with Ran:GTP
[Reaction:R-HSA-180627] Interaction of Vpr with importin alpha
[Reaction:R-HSA-167077] Recruitment of elongation factors to form HIV-1 elongation complex
[Reaction:R-HSA-167090] 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
[Reaction:R-HSA-165027] Rev molecules assemble onto the RRE RNA sequence through their ARM sequence
[Reaction:R-HSA-167148] TFIIS-mediated recovery of elongation from arrest
[Pathway:R-HSA-167590] Nef Mediated CD4 Down-regulation
[Reaction:R-HSA-167630] Formation of Nef CD28 cytoplasmic tail complex
[Reaction:R-HSA-182186] Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex
[Reaction:R-HSA-167098] Phosphorylation (Ser5) of RNA pol II CTD
[Reaction:R-HSA-167566] Nef mediated disruption of CD4:Lck Complex
[Reaction:R-HSA-182243] Formation of MHC I:Nef Complex
[Reaction:R-HSA-162590] Import of PIC to the Host Nucleus
[Reaction:R-HSA-200952] Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction
[Reaction:R-HSA-200879] Formation of a Nef:ARF1:CD4 complex
[Pathway:R-HSA-164516] Minus-strand DNA synthesis
[Reaction:R-HSA-164521] Insertion of gp41 fusion peptide into the target membrane
[Pathway:R-HSA-162592] Integration of provirus
[Pathway:R-HSA-162909] Host Interactions of HIV factors
[Pathway:R-HSA-162585] Uncoating of the HIV Virion
[Pathway:R-HSA-164944] Nef and signal transduction
[Reaction:R-HSA-164513] 3' PPT-primed initiation of plus-strand DNA synthesis
[Reaction:R-HSA-164509] Binding of gp120 of ENV oligomer to the host CD4
[Reaction:R-HSA-164528] RNase H-mediated cleavage of the template strand
[Reaction:R-HSA-164519] RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex
[Reaction:R-HSA-182876] Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
[Reaction:R-HSA-200908] Nef Binds and activates the Src-family tyrosine kinase Fyn
[Reaction:R-HSA-167115] Addition of nucleotides between position +11 and +30 on HIV-1 transcript
[Reaction:R-HSA-164500] Conformational changes in gp120 exposes gp41
[Reaction:R-HSA-167128] RNA Polymerase II CTD (phosphorylated) binds to CE
[Pathway:R-HSA-175567] Integration of viral DNA into host genomic DNA
[Pathway:R-HSA-167162] RNA Polymerase II HIV Promoter Escape
[Reaction:R-HSA-164505] Synthesis of full-length duplex viral DNA with a discontinuous plus strand
[Reaction:R-HSA-200954] Nef Binds and activates the Src-family tyrosine kinase Lck
[Reaction:R-HSA-167537] Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex
[Reaction:R-HSA-164503] First strand transfer mediated by Repeated (R) sequence
[BlackBoxEvent:R-HSA-180603] Proteosome-mediated degradation of APOBEC3G
[Pathway:R-HSA-167290] Pausing and recovery of HIV elongation
[Reaction:R-HSA-167459] Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex)
[Depolymerisation:R-HSA-173642] Disintegration of matrix layer
[Reaction:R-HSA-167597] Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
[Reaction:R-HSA-164524] Fusion of viral membrane with host cell membrane
[Reaction:R-HSA-167111] Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex
[Reaction:R-HSA-164512] Second strand transfer by annealing complementary PBS sequences
[Pathway:R-HSA-177243] Interactions of Rev with host cellular proteins
[Reaction:R-HSA-175258] 2-LTR formation due to circularization of viral DNA
[Pathway:R-HSA-182218] Nef Mediated CD8 Down-regulation
[Reaction:R-HSA-182279] Formation of MHC I:Nef:AP-1:PACS-1 Complex
[Reaction:R-HSA-180602] Association of Vif with APOBEC3G
[Reaction:R-HSA-173771] Formation of RTC (Reverse Transcription Complex)
[Reaction:R-HSA-167477] Abortive HIV-1 initiation after formation of the first phosphodiester bond
[Reaction:R-HSA-200858] Nef Binds and activates the Src-family tyrosine kinase Hck
[Reaction:R-HSA-164522] Terminal (3' end) cleavage of viral DNA
[Reaction:R-HSA-167633] Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex
[Reaction:R-HSA-180555] Association of APOBEC3G:Vif with the Cul5-SCF complex
[Reaction:R-HSA-175108] Target DNA binding
[Pathway:R-HSA-167160] RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
[Reaction:R-HSA-167637] Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex
[Reaction:R-HSA-175117] 1-LTR circle formation
[Reaction:R-HSA-9697051] RTC binds NRTIs
[Reaction:R-HSA-167292] Resumption of elongation of HIV-1 transcript after recovery from pausing
[Reaction:R-HSA-164507] CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4
[BlackBoxEvent:R-HSA-182263] Degradation of MHC I Complex
[Reaction:R-HSA-182859] RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex
[Reaction:R-HSA-173769] RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers
[Pathway:R-HSA-180585] Vif-mediated degradation of APOBEC3G
[Pathway:R-HSA-164939] Nef mediated downregulation of CD28 cell surface expression
[Reaction:R-HSA-175174] Association of Ku heterodimer with viral DNA ends
[Reaction:R-HSA-164515] Fusogenic activation of gp41
[Reaction:R-HSA-182198] Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex
[Pathway:R-HSA-164525] Plus-strand DNA synthesis
[Reaction:R-HSA-182286] Transport of MHC I:Nef:AP-1:PACS-1 Complex
[Reaction:R-HSA-164506] Gap repair completes provirus integration
[BlackBoxEvent:R-HSA-182171] Degradation of CD8
[Reaction:R-HSA-167117] Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition
[Pathway:R-HSA-167172] Transcription of the HIV genome
[Reaction:R-HSA-182795] RNase H-mediated degradation of the template strand
[Reaction:R-HSA-167282] 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
[Pathway:R-HSA-167243] Tat-mediated HIV elongation arrest and recovery
[BlackBoxEvent:R-HSA-167601] Degradation of CD4
[Pathway:R-HSA-164940] Nef mediated downregulation of MHC class I complex cell surface expression
[Reaction:R-HSA-8951690] Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1
[Reaction:R-HSA-164527] Annealing of 3'-end of unwound transfer RNA primer with genomic RNA
[Pathway:R-HSA-164938] Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
[Pathway:R-HSA-177539] Autointegration results in viral DNA circles
[Reaction:R-HSA-164523] Transesterification to connect viral DNA 3' ends to host DNA 5' ends
[Pathway:R-HSA-162589] Reverse Transcription of HIV RNA
[Reaction:R-HSA-184269] Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex
[BlackBoxEvent:R-HSA-187213] Synthesis of GAG polyprotein
[Reaction:R-HSA-171288] Cleavage of the viral Env gp160 precursor polyprotein
[Reaction:R-HSA-174493] Glycosylation of ENV polyprotein
[Reaction:R-HSA-3149432] Transport of VPU to Plasma Membrane
[BlackBoxEvent:R-HSA-184323] Monoubiquitination of N-myristoyl GAG polyprotein
[Reaction:R-HSA-184392] N-myristoylation of GAG polyprotein by NMT2
[BlackBoxEvent:R-HSA-187211] Splicing of HIV RNA transcript
[Pathway:R-HSA-175474] Assembly Of The HIV Virion
[BlackBoxEvent:R-HSA-3149433] Synthesis of VPU protein
[Reaction:R-HSA-3139027] Maturation of HIV Virion
[Pathway:R-HSA-162594] Early Phase of HIV Life Cycle
[Reaction:R-HSA-173647] Transport of trimeric gp41:gp120 to plasma membrane
[BlackBoxEvent:R-HSA-3159227] HIV Virion Budding
[Reaction:R-HSA-3149454] Packaging of HIV virion on the host cell plasma membrane
[Pathway:R-HSA-162588] Budding and maturation of HIV virion
[Reaction:R-HSA-9697043] Protease binds protease inhibitors
[Reaction:R-HSA-174491] Transport of trimeric ENV precursor to Golgi apparatus
[Pathway:R-HSA-171286] Synthesis and processing of ENV and VPU
[Reaction:R-HSA-3159232] Recruitment Of HIV Virion Budding Machinery
[Reaction:R-HSA-3149434] Transport of GAG to the Plasma Membrane
[Pathway:R-HSA-174495] Synthesis And Processing Of GAG, GAGPOL Polyproteins
[Reaction:R-HSA-171291] Folding and Oligomerization of ENV glycoprotein
[BlackBoxEvent:R-HSA-174494] Synthesis of ENV polyprotein
[Pathway:R-HSA-162906] HIV Infection
[Reaction:R-HSA-162914] Myristoylation of Nef
[Pathway:R-HSA-162587] HIV Life Cycle
[Reaction:R-HSA-3149440] Transport of VPU to Golgi apparatus
[Pathway:R-HSA-162599] Late Phase of HIV Life Cycle
[Pathway:R-HSA-174490] Membrane binding and targetting of GAG proteins
[Pathway:R-HSA-173107] Binding and entry of HIV virion
[Reaction:R-HSA-175250] Suicidal integration leading to smaller circles of viral DNA
[Reaction:R-HSA-164514] Integrase binds viral DNA ends
[Reaction:R-HSA-164510] Conformational change in gp120 of Env oligomer
[Reaction:R-HSA-164504] Synthesis of minus strand strong stop DNA (-sssDNA)
[Pathway:R-HSA-167161] HIV Transcription Initiation
[Reaction:R-HSA-164520] Minus strand DNA synthesis resumes
[Reaction:R-HSA-173115] Formation of Pre-Integration Complex (PIC)
[Reaction:R-HSA-164845] Suicidal integration leading to inverted circle formation
[Reaction:R-HSA-180540] Multi-ubiquitination of APOBEC3G
[Reaction:R-HSA-173111] Disassembly of viral capsid
[Reaction:R-HSA-164943] Nef mediated activation of the T-cell receptor
[Reaction:R-HSA-167484] Fall Back to Closed Pre-initiation Complex
[Reaction:R-HSA-164508] N and C terminal heptad repeat helices of gp41 form six-helix bundle
[Reaction:R-HSA-167133] Activation of GT
[Reaction:R-HSA-167153] SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
[Reaction:R-HSA-167468] Abortive HIV-1 Initiation After Second Transition
[Pathway:R-HSA-164843] 2-LTR circle formation

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