Reactome Pathway Database

Schema > Reaction > Entries

The Vpu:CD4:beta-TrCP complex recruits SKP1 Show undefined attributes

authored

[InstanceEdit:180608] Matthews, L, 2006年05月15日 07:16:46

category binding

compartment

created [InstanceEdit:180586] Matthews, L, 2006年05月23日 13:59:44

crossReference

[DatabaseIdentifier:11944912] Mondo:0005109

dbId 180599

disease

[Disease:1660559] Human immunodeficiency virus infectious disease

displayName The Vpu:CD4:beta-TrCP complex recruits SKP1

edited

[InstanceEdit:180608] Matthews, L, 2006年05月15日 07:16:46

eventOf

[Pathway:R-HSA-180534] Vpu mediated degradation of CD4 - Homo sapiens

followingEvent

[Reaction:R-HSA-180597] Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex - Homo sapiens

input

isInDisease true

isInferred false

literatureReference

[LiteratureReference:180533] A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

The Vpu:CD4:beta-TrCP complex recruits SKP1

output

[Complex:R-HSA-180592] CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane]

precedingEvent

[Reaction:R-HSA-180591] Vpu:CD4 associates with beta-TrCP - Homo sapiens

relatedSpecies

[Species:164493] Human immunodeficiency virus 1

releaseDate 2006年11月14日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:188242] Benarous, R, 2006年09月21日 14:25:23

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-180599

summation

[Summation:188233] The SKP1 component of the SCF complex is recruited to the Vp...

Referrals

(precedingEvent)

[Reaction:R-HSA-180597] Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex

(hasEvent)

[Pathway:R-HSA-180534] Vpu mediated degradation of CD4

© 2025 Reactome

Cite Us!