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Schema
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Reaction
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Entries
Nef Binds and activates the Src-family tyrosine kinase Hck
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authored
[InstanceEdit:200905] Gillespie, ME, 2007年07月25日 19:42:36
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:200838] Gillespie, ME, 2007年07月25日 19:41:34
crossReference
[DatabaseIdentifier:11944912] Mondo:0005109
dbId
200858
disease
[Disease:1660559] Human immunodeficiency virus infectious disease
displayName
Nef Binds and activates the Src-family tyrosine kinase Hck
eventOf
[Pathway:R-HSA-164944] Nef and signal transduction - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-167708] HCK [cytosol]
[EntityWithAccessionedSequence:R-HIV-167605] myristoylated nef [cytosol]
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:200866] Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement
[LiteratureReference:200833] Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4
[LiteratureReference:200897] The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Nef Binds and activates the Src-family tyrosine kinase Hck
output
[Complex:R-HSA-200872] Hck-1:Nef [cytosol]
relatedSpecies
[Species:164493] Human immunodeficiency virus 1
releaseDate
2005年09月26日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:201388] Skowronski, J, 2007年08月07日 14:33:41
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-200858
summation
[Summation:200863] The protein Hck is a member of the Src family of non-recepto...
updateTrackers
[UpdateTracker:9788059] Update Tracker - [Reaction:200858] Nef Binds and activates the Src-family tyrosine kinase Hck - v44:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9788059] Update Tracker - [Reaction:200858] Nef Binds and activates the Src-family tyrosine kinase Hck - v44:[add_removeInput]
(hasEvent)
[Pathway:R-HSA-164944] Nef and signal transduction
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