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Entries
RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex
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authored
[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006年05月18日 20:10:22
catalystActivity
[CatalystActivity:173785] RNA-DNA hybrid ribonuclease activity of RTC with minus sssDNA:tRNA primer:RNA template [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:164501] D'Eustachio, P, 2005年05月24日 15:07:45
crossReference
[DatabaseIdentifier:11944912] Mondo:0005109
dbId
164519
disease
[Disease:1660559] Human immunodeficiency virus infectious disease
displayName
RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex
edited
[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006年05月18日 20:10:22
eventOf
[Pathway:R-HSA-164516] Minus-strand DNA synthesis - Homo sapiens
figure
[Figure:180423] /figures/RT_event2.jpg
followingEvent
[Reaction:R-HSA-182859] RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex - Homo sapiens
input
[Complex:R-HSA-173774] RTC with minus sssDNA:tRNA primer:RNA template [cytosol]
isInDisease
true
isInferred
false
literatureReference
[Book:175762] 9780879695712 Reverse Transcriptase and the Generation of Retroviral DNA Retroviruses Coffin, JM
[LiteratureReference:177451] Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities.
[LiteratureReference:177439] Truncating alpha-helix E' of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer
[LiteratureReference:175646] The HIV-1 reverse transcription (RT) process as target for RT inhibitors
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex
output
[Complex:R-HSA-182804] RTC with nicked minus sssDNA:tRNA primer:RNA template [cytosol]
precedingEvent
[Reaction:R-HSA-164504] Synthesis of minus strand strong stop DNA (-sssDNA) - Homo sapiens
relatedSpecies
[Species:164493] Human immunodeficiency virus 1
releaseDate
2006年11月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:188936] Hughes, SH, 2006年10月30日 22:00:51
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-164519
summation
[Summation:177462] As the reverse transcriptase activity of the HIV-1 RT hetero...
Referrals
(hasEvent)
[Pathway:R-HSA-164516] Minus-strand DNA synthesis
(precedingEvent)
[Reaction:R-HSA-182859] RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex
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