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Entries
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
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authored
[InstanceEdit:165064] Matthews, L, Rice, AP, 2005年07月27日 00:00:00
catalystActivity
[CatalystActivity:113431] protein serine/threonine kinase activity of P-TEFb complex [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:167073] Matthews, L, 2005年10月11日 08:25:49
crossReference
[DatabaseIdentifier:11944912] Mondo:0005109
dbId
167084
disease
[Disease:1660559] Human immunodeficiency virus infectious disease
displayName
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
edited
[InstanceEdit:165066] Matthews, L, 2005年07月26日 23:29:22
eventOf
[Pathway:R-HSA-167152] Formation of HIV elongation complex in the absence of HIV Tat - Homo sapiens
followingEvent
[Reaction:R-HSA-170706] Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex - Homo sapiens
[Reaction:R-HSA-167077] Recruitment of elongation factors to form HIV-1 elongation complex - Homo sapiens
inferredFrom
[Reaction:R-HSA-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Homo sapiens
input
11 ×
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[Complex:R-HSA-167078] DSIF:NELF:early elongation complex [nucleoplasm]
[Complex:R-HSA-112431] P-TEFb complex [nucleoplasm]
isInDisease
true
isInferred
true
literatureReference
[LiteratureReference:170692] Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor
[LiteratureReference:170763] Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
output
11 ×
[SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
[Complex:R-HSA-77088] Cap Binding Complex (CBC) [nucleoplasm]
[Complex:R-HSA-167075] HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm]
precedingEvent
[Reaction:R-HSA-167085] Formation of DSIF:NELF:HIV-1 early elongation complex - Homo sapiens
[Reaction:R-HSA-112430] Formation of P-TEFb complex - Homo sapiens
relatedSpecies
[Species:164493] Human immunodeficiency virus 1
releaseDate
2005年06月13日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-167084
summation
[Summation:170742] The association between Tat, TAR and P-TEFb is believed to b...
updateTrackers
[UpdateTracker:9784473] Update Tracker - [Reaction:167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - v54:[addLiteratureReference]
[UpdateTracker:9779207] Update Tracker - [Reaction:167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - v66:[addInput, addOutput]
Referrals
(updatedInstance)
[UpdateTracker:9784473] Update Tracker - [Reaction:167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - v54:[addLiteratureReference]
[UpdateTracker:9779207] Update Tracker - [Reaction:167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - v66:[addInput, addOutput]
(precedingEvent)
[Reaction:R-HSA-170706] Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
[Reaction:R-HSA-167077] Recruitment of elongation factors to form HIV-1 elongation complex
(hasEvent)
[Pathway:R-HSA-167152] Formation of HIV elongation complex in the absence of HIV Tat
(inferredTo)
[Reaction:R-HSA-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
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