Glycoscience: Biology and Medicine

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Editors:

• Tamao Endo ⁰ ,
• Peter H. Seeberger ¹ ,
• Gerald W. Hart ² ,
• Chi-Huey Wong ³ ,
• …
• Naoyuki Taniguchi ⁴

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1. Tamao Endo

   1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
      

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2. Peter H. Seeberger

   1. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany
      

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3. Gerald W. Hart

   1. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA
      

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4. Chi-Huey Wong

   1. Academia Sinica, Nankang, Taipei, Taiwan
      

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5. Naoyuki Taniguchi

   1. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Japan
      

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The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies.
Glycans (carbohydrate oligomers) are the so-called "building blocks" of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book will provide numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

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1. 3D-Lectin Database

   • Serge Pérez, Alain Rivet, Anne Imberty

2. A Glycan Marker for Idiopathic Normal Pressure Hydrocephalus

   • Kyoka Hoshi, Yuka Matsumoto, Toshie Saito, Hiromi Ito, Yoshinobu Kariya, Yoshiki Yamaguchi et al.

3. A Novel Antibody for Keratan Sulfate Expressed on Human iPS/ES Cells

   • Toshisuke Kawasaki, Nobuko Kawasaki, Hiromi Nakao, Hidenao Toyoda

4. Acid-Base Catalysis Concept in Glycosidation

   • Amit Kumar, Richard R. Schmidt

5. Analysis of Sulfoglycolipids by Mass Spectrometry

   • Michael Tiemeyer, Kazuhiro Aoki

6. Automated Programmable One-Pot Synthesis of Glycans

   • Chung-Yi Wu, Chi-Huey Wong

7. Automation in Glycan Synthesis

   • Chung-Yi Wu, Chi-Huey Wong

8. Bacterial, Plant, and Fungal Carbohydrate Structure Database (CSDB)

   • Philip Toukach, Ksenia Egorova

9. Binding of Influenza Viruses to Glycans

   • Tadanobu Takahashi, Takashi Suzuki

10. Biological Functions of C1GalT1 and Mucin-Type O-Glycans

    • Kirk Bergstrom, Jianxin Fu, Lijun Xia

11. C-Mannosylation: A Modification on Tryptophan in Cellular Proteins

    • Yoshito Ihara, Yoko Inai, Midori Ikezaki, In-Sook L. Matsui, Shino Manabe, Yukishige Ito

12. C-Type Lectins

    • Timo Johannssen, Julia Hütter, Stephanie Zimmermann, Bernd Lepenies

13. Capillary Electrophoresis of Glycans: Validation of Antibody Pharmaceuticals Based on Glycan Profiles

    • Mitsuhiro Kinoshita, Kazuaki Kakehi

14. Carbohydrate-Based Gamete Recognition During the Sperm Acrosome Reaction in Sea Urchins

    • Noritaka Hirohashi

15. Chemical Synthesis of Homogeneous Glycoproteins

    • Masayuki Izumi, Ryo Okamoto, Yasuhiro Kajihara

16. Chemical Synthesis of Oligosialic Acid by Using 5-N,4-O-Carbonyl-Protected Sialyl Donors

    • Hiroshi Tanaka

17. Chemical Tools to Detect and Target Helicobacter pylori’s Glycoproteins

    • Van N. Tra, Danielle H. Dube

18. Chemo-Enzymatic Synthesis of Glycans : Overview

    • Chi-Huey Wong

19. Chemoenzymatic Synthesis of Glycoproteins

    • Guohui Zhao, Yunpeng Liu, Zhigang Wu, Hailiang Zhu, Zaikuan Yu, Junqiang Fang et al.

20. Chemoenzymatic Synthesis of Heparin

    • Demetria M. Dickinson, Jian Liu, Robert J. Linhardt

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• Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

  Tamao Endo

• Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

  Peter H. Seeberger

• Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA

  Gerald W. Hart

• Academia Sinica, Nankang, Taipei, Taiwan

  Chi-Huey Wong

• Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Japan

  Naoyuki Taniguchi

Naoyuki Taniguchi is with RIKEN, Japan.
Tamao Endo is with Tokyo. Metropolitan Institute of Gerontology, Japan.
Gerald Hart is with Johns Hopkins University, USA.
Peter Seeberger is with Max Planck Institute, Germany.
Chi-Huey Wong is with Academia Sinica, Taiwan.
The co-editors are Jin-ichi Inokuchi, Ken Kitajima, Shoko Nishihara, Yasuhiro Kajihara, Kenji Kadomatsu, Takashi Angata, and Yoshiki Yamaguchi.

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