Glycoscience: Biology and Medicine

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Editors:

• Tamao Endo ⁰ ,
• Peter H. Seeberger ¹ ,
• Gerald W. Hart ² ,
• Chi-Huey Wong ³ ,
• …
• Naoyuki Taniguchi ⁴

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1. Tamao Endo

   1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
      

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2. Peter H. Seeberger

   1. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany
      

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3. Gerald W. Hart

   1. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA
      

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4. Chi-Huey Wong

   1. Academia Sinica, Nankang, Taipei, Taiwan
      

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5. Naoyuki Taniguchi

   1. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Japan
      

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The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies.
Glycans (carbohydrate oligomers) are the so-called "building blocks" of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book will provide numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

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1. Glycotranscriptomics

   • Alison Nairn, Kelley Moremen

2. GM3 Synthase (ST3Gal5) and Diabetes

   • Jin-ichi Inokuchi

3. Helicobacter pylori

   • Masatomo Kawakubo, Yuki Ito, Minoru Fukuda, Jun Nakayama

4. Heparan Sulfate Proteoglycans in Drosophila melanogaster

   • Keisuke Kamimura, Nobuaki Maeda

5. Heparan Sulfate Proteoglycans in the Drosophila Ovarian Germline Stem Cell Niche

   • Hiroshi Nakato

6. Hepatosteatosis and Primary Hepatoma

   • Eiji Miyoshi, Yoshihiro Kamada

7. Heterologous Glycoprotein Production (Plant)

   • Kazuhito Fujiyama

8. Heterologous Glycoprotein Production (Yeast )

   • Yasunori Chiba

9. Historical and Practical Aspects of the Development of the Lectin Microarray Technique

   • Jun Hirabayashi

10. HIV and Galectins

    • Michel Ouellet, Michel J. Tremblay, Sachiko Sato

11. HNK-1 Glyco-epitope: Complex Machinery for the Biosynthesis

    • Naoki Nakagawa, Shogo Oka

12. Homogeneous Glycoproteins, Overview

    • Chi-Huey Wong

13. Hyaluronan: Cancer and Cancer Metastasis

    • Theerawut Chanmee, Pawared Ontong, Naoki Itano

14. Identification of Mammalian O-Mannosylated Glycopeptides

    • Patrick R. Winterhalter, Thomas Ruppert, Sabine Strahl

15. Imaging by Click Chemistry

    • Chung-Yi Wu, Chi-Hui Wong

16. Imaging Cell-Surface Glycans in Animals with Bioorthogonal Chemistry

    • Brendan J. Beahm, Carolyn R. Bertozzi

17. Immunoglycobiology: An Overview

    • Ada G. Blidner, Juan M. Ilarregui, Gabriel A. Rabinovich

18. Indirect Detection of Hydroxy Proton Exchange Through Deuterium-Induced13C-NMR Isotope Shifts

    • Shinya Hanashima, Yoshiki Yamaguchi

19. Influenza Virus, Overview: Structures, Infection Mechanisms and Antivirals

    • Raphael Böhm, Thomas Haselhorst, Mark von Itzstein

20. Integrin α5β1 and Its N-glycosylation

    • Jianguo Gu, Qinglei Hang, Tomohiko Fukuda, Tomoya Isaji

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• Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

  Tamao Endo

• Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

  Peter H. Seeberger

• Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA

  Gerald W. Hart

• Academia Sinica, Nankang, Taipei, Taiwan

  Chi-Huey Wong

• Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Japan

  Naoyuki Taniguchi

Naoyuki Taniguchi is with RIKEN, Japan.
Tamao Endo is with Tokyo. Metropolitan Institute of Gerontology, Japan.
Gerald Hart is with Johns Hopkins University, USA.
Peter Seeberger is with Max Planck Institute, Germany.
Chi-Huey Wong is with Academia Sinica, Taiwan.
The co-editors are Jin-ichi Inokuchi, Ken Kitajima, Shoko Nishihara, Yasuhiro Kajihara, Kenji Kadomatsu, Takashi Angata, and Yoshiki Yamaguchi.

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