Glycoscience: Biology and Medicine

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Editors:

• Tamao Endo ⁰ ,
• Peter H. Seeberger ¹ ,
• Gerald W. Hart ² ,
• Chi-Huey Wong ³ ,
• …
• Naoyuki Taniguchi ⁴

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1. Tamao Endo

   1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
      

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2. Peter H. Seeberger

   1. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany
      

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3. Gerald W. Hart

   1. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA
      

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4. Chi-Huey Wong

   1. Academia Sinica, Nankang, Taipei, Taiwan
      

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5. Naoyuki Taniguchi

   1. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Japan
      

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The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies.
Glycans (carbohydrate oligomers) are the so-called "building blocks" of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book will provide numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

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1. FGF System and GAGs

   • Toru Imamura

2. Flagellasialin: A Highly Glycosylated GPI-Anchored Protein Involved in Intracellular Ca2+ Regulation in Sea Urchin Sperm

   • Takeru Kanazawa, Eriko Suzuki, Shinji Miyata, Chihiro Sato, Ken Kitajima

3. Free Complex-Type N-Glycans

   • Yasuhide Miyamoto

4. Free Oligosaccharides (High Mannose-Type Free Glycans Found in Mammals and Yeast)

   • Tadashi Suzuki

5. Functional Analysis of Glycans Using Drosophila Mutants and RNAi

   • Takashi J. Fuwa, Shoko Nishihara

6. Functional Regulation of ErbB Receptors by N-Glycans

   • Motoko Takahashi

7. Functional Roles of O-GlcNAc in Cell Signaling

   • Jin Won Cho, Sujin Park

8. Ganglioside Synthesis

   • Makoto Kiso, Hideharu Ishida, Hiromune Ando, Akihiro Imamura

9. Gangliosides in Axon Stability and Regeneration

   • Ronald L. Schnaar

10. Gangliosides in T Cell Immunity

    • Masakazu Nagafuku, Jin-ichi Inokuchi

11. Gangliosides: Synthesis and Function in Nervous Tissues

    • Koichi Furukawa, Yuhsuke Ohmi, Yuki Ohkawa, Noboru Hashimoto, Yoshio Yamauchi, Orie Tajima et al.

12. Generating Isoform-Specific Antibodies: Lessons from the Nucleocytoplasmic Glycoprotein Skp1

    • Christopher M. West, Hanke van der Wel, Zoiesha Chinoy, Geert-Jan Boons, Ted J. Gauthier, Carol M. Taylor et al.

13. Glc Transporter Assay and the New Intestinal Glycobiology

    • Kimie Asanuma-Date, Haruko Ogawa

14. GLUT2

    • Kazuaki Ohtsubo

15. Glycan Functions and Signals in Embryonic Stem Cells

    • Shoko Nishihara

16. Glycans Against NK Tumor Immunity

    • Shigeru Tsuboi

17. Glycation of Proteins

    • Motoko Takahashi

18. Glyco-engineered Therapeutic Antibodies as a Second-Generation Antibody Therapy

    • Rinpei Niwa, Kenya Shitara, Mitsuo Satoh

19. Glycoantigen and Xenotransplantation

    • Akira Maeda, Hiroshi Eguchi, Takuji Kawamura, Hiroomi Okuyama, Shuji Miyagawa

20. Glycoconjugate Antigens in Neural Stem Cells

    • Yutaka Itokazu, Robert K. Yu

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• Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

  Tamao Endo

• Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

  Peter H. Seeberger

• Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA

  Gerald W. Hart

• Academia Sinica, Nankang, Taipei, Taiwan

  Chi-Huey Wong

• Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Japan

  Naoyuki Taniguchi

Naoyuki Taniguchi is with RIKEN, Japan.
Tamao Endo is with Tokyo. Metropolitan Institute of Gerontology, Japan.
Gerald Hart is with Johns Hopkins University, USA.
Peter Seeberger is with Max Planck Institute, Germany.
Chi-Huey Wong is with Academia Sinica, Taiwan.
The co-editors are Jin-ichi Inokuchi, Ken Kitajima, Shoko Nishihara, Yasuhiro Kajihara, Kenji Kadomatsu, Takashi Angata, and Yoshiki Yamaguchi.

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