Glycoscience: Biology and Medicine

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Editors:

• Tamao Endo ⁰ ,
• Peter H. Seeberger ¹ ,
• Gerald W. Hart ² ,
• Chi-Huey Wong ³ ,
• …
• Naoyuki Taniguchi ⁴

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1. Tamao Endo

   1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
      

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2. Peter H. Seeberger

   1. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany
      

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3. Gerald W. Hart

   1. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA
      

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4. Chi-Huey Wong

   1. Academia Sinica, Nankang, Taipei, Taiwan
      

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5. Naoyuki Taniguchi

   1. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Japan
      

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The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies.
Glycans (carbohydrate oligomers) are the so-called "building blocks" of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book will provide numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

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1. Glycoenzymes in Glycan Analysis and Synthesis

   • Toshihiko Katoh, Kenji Yamamoto

2. GlycoEpitope: A Database for Carbohydrate Antigen and Antibody

   • Shujiro Okuda, Hiromi Nakao, Toshisuke Kawasaki

3. Glycoform Imaging

   • Yoshimi Haga, Tadashi Suzuki

4. Glycoinformatics Overview

   • Kiyoko F. Aoki-Kinoshita

5. Glycolipid Raft

   • Kazuya Kabayama, Hisao Kojima, Yusuke Suzuki

6. Glycomarkers

   • J. Michael Pierce

7. GlycomeDB

   • Rene Ranzinger, William S. York

8. Glycomimetic Drugs: A Source of Novel Therapeutics

   • John L. Magnani

9. Glycopeptide/Glycoprotein Synthesis

   • Ci Xu, Xuechen Li

10. Glycoredox: A New Paradigm for Glycosylation and Redox Signaling Research

    • Rina Takamiya, Kazuaki Ohtsubo, Naoyuki Taniguchi

11. Glycosaminoglycans in Embryonic and Induced Pluripotent Stem Cells

    • Hidenao Toyoda, Akiko-Kinoshita Toyoda

12. Glycosaminoglycans: A Key Regulator for Recovery from Neuronal Injuries

    • Kenji Kadomatsu

13. Glycosaminoglycans: Their Modes of Action for a Possible New Avenue for Therapeutic Intervention

    • Tadahisa Mikami, Hiroshi Kitagawa

14. Glycosphingolipid Analysis by Liquid Chromatography–Mass Spectrometry

    • Akemi Suzuki, Kunihiro Sano, Minoru Suzuki, Yoshikatsu Umemura, Hideshi Fujiwake

15. Glycosphingolipid–Receptor Interactions in the Innate Immune Response

    • Hitoshi Nakayama, Kazuhisa Iwabuchi

16. Glycosylation

    • David Crich

17. Glycosylation Density in Cellular Homeostasis

    • C. Fred Brewer

18. Glycosylation in Cancer: Enzymatic Basis for Alterations in N-Glycan Branching

    • Hiroaki Korekane, Naoyuki Taniguchi

19. Glycosylation in High Endothelial Venules

    • Hiroto Kawashima

20. Glycosylation of Amyloid β-Precursor Protein

    • Shinobu Kitazume

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• Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

  Tamao Endo

• Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

  Peter H. Seeberger

• Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA

  Gerald W. Hart

• Academia Sinica, Nankang, Taipei, Taiwan

  Chi-Huey Wong

• Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Japan

  Naoyuki Taniguchi

Naoyuki Taniguchi is with RIKEN, Japan.
Tamao Endo is with Tokyo. Metropolitan Institute of Gerontology, Japan.
Gerald Hart is with Johns Hopkins University, USA.
Peter Seeberger is with Max Planck Institute, Germany.
Chi-Huey Wong is with Academia Sinica, Taiwan.
The co-editors are Jin-ichi Inokuchi, Ken Kitajima, Shoko Nishihara, Yasuhiro Kajihara, Kenji Kadomatsu, Takashi Angata, and Yoshiki Yamaguchi.

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