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Abstract
Ganglioside GM3 has been known to participate in insulin signaling by regulating the association of insulin receptor in caveolae microdomains (lipid rafts). Studies on the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 in adipocytes lead to a working hypothesis "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides." It is expected the development of novel diagnosis of metabolic syndrome by identifying the specific ganglioside species and a therapeutic strategy "membrane microdomain ortho-signaling therapy."
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Editors and Affiliations
Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
Tamao Endo
Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany
Peter H. Seeberger
Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Gerald W. Hart
Academia Sinica, Nankang, Taipei, Taiwan
Chi-Huey Wong
Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Saitama, Japan
Naoyuki Taniguchi
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© 2014 Springer Japan
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Inokuchi, Ji. (2014). GM3 Synthase (ST3Gal5) and Diabetes . In: Endo, T., Seeberger, P., Hart, G., Wong, CH., Taniguchi, N. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54836-2_210-1
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DOI: https://doi.org/10.1007/978-4-431-54836-2_210-1
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Publisher Name: Springer, Tokyo
Online ISBN: 978-4-431-54836-2
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