- Kirk Bergstrom 6 ,
- Jianxin Fu 6 &
- Lijun Xia 6,7
-
124 Accesses
Abstract
O-linked glycosylation is an important posttranslational modification of proteins. O-linked N-acetylgalactosamine (O-GalNAc) glycans are a major O-glycan subtype found in most cells and tissues on a wide range of proteins with diverse functions. Mucin family molecules are among the best studied O-GalNAc glycoproteins, possessing hundreds of O-glycosylation sites in repeated domains rich in Ser/Thr; hence O-GalNAc glycans are also called mucin-type O-glycans. Mucins are highly expressed at mucosal surfaces, interfacing with the environment and protecting against noxious stimuli. Numerous mucin-like glycoproteins are also modified by O-GalNAc glycans that regulate immune cell trafficking and inflammation (e.g., PSGL-1, CD44) or vascular development and integrity (e.g., podoplanin). O-Glycosylation is highly regulated in every tissue and subject to alteration by diverse stimuli and pathologic states. Mucin-type O-glycans thus have critical physiologic functions that influence development, host-environment interactions, and disease pathogenesis.
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Acknowledgments
Work was supported by grants from the National Institute of Health (DK085691 and HL085607), Crohn’s and Colitis Foundation of America (#285148), and American Heart Association (SDG7410022).
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Editors and Affiliations
Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
Tamao Endo
Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany
Peter H. Seeberger
Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Gerald W. Hart
Academia Sinica, Nankang, Taipei, Taiwan
Chi-Huey Wong
Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Saitama, Japan
Naoyuki Taniguchi
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© 2014 Springer Japan
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Bergstrom, K., Fu, J., Xia, L. (2014). Biological Functions of C1GalT1 and Mucin-Type O-Glycans. In: Endo, T., Seeberger, P., Hart, G., Wong, CH., Taniguchi, N. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54836-2_65-1
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DOI: https://doi.org/10.1007/978-4-431-54836-2_65-1
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Publisher Name: Springer, Tokyo
Online ISBN: 978-4-431-54836-2
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