Eutylone
From Wikipedia, the free encyclopedia
Designer drug of the cathinone class
Pharmaceutical compound
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| Formula | C13H17NO3 |
| Molar mass | 235.283 g·mol−1 |
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Eutylone (also known as β-keto-1,3-benzodioxolyl-N-ethylbutanamine, bk-EBDB, and N-ethylbutylone) is a stimulant and empathogenic drug of the phenethylamine, amphetamine, phenylisobutylamine, and cathinone families which was developed in the 1960s,[3] [4] which is classified as a designer drug.[5] It was first reported to the EMCDDA in 2014 and became widespread internationally in 2019-2020 following bans on the related compound ephylone.[6] [7] [8] [9] It is a synthetic cathinone.[9] In 2021, eutylone was the most common cathinone identified by the Drug Enforcement Administration in the United States.[10]
Pharmacology
[edit ]| DAT | NET | SERT |
|---|---|---|
| 120 ± 10 | 1280 ± 140 | 690 ± 50 |
Legal status
[edit ]Sweden's public health agency suggested classifying eutylone as a hazardous substance, on September 25, 2019.[11]
In the United States Eutylone is considered a schedule 1 controlled substance as a positional isomer of Pentylone.[12] [13]
See also
[edit ]- 5-Methylethylone
- Butylone
- Ethyl-J
- Ethylone
- Ephylone
- N-Ethylhexedrone
- N-Ethylhexylone
- N-Ethylheptylone
References
[edit ]- ^ Anvisa (2023年07月24日). "RDC No 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023年07月25日). Archived from the original on 2023年08月27日. Retrieved 2023年08月27日.
- ^ "Substance Details Eutylone" . Retrieved 2024年01月22日.
- ^ GB 108513, "Aryl-α-aminoketone derivatives", published 1967年09月27日, assigned to Boehringer Ingelheim
- ^ a b Glatfelter GC, Walther D, Evans-Brown M, Baumann MH (April 2021). "Eutylone and Its Structural Isomers Interact with Monoamine Transporters and Induce Locomotor Stimulation". ACS Chemical Neuroscience. 12 (7): 1170–1177. doi:10.1021/acschemneuro.0c00797. PMC 9423000 . PMID 33689284. S2CID 232192447.
- ^ "Eutylone". New Synthetic Drugs Database. 12 November 2023.
- ^ Bade R, White JM, Nguyen L, Tscharke BJ, Mueller JF, O'Brien JW, et al. (August 2020). "Determining changes in new psychoactive substance use in Australia by wastewater analysis" . The Science of the Total Environment. 731 139209. Bibcode:2020ScTEn.73139209B. doi:10.1016/j.scitotenv.2020.139209. PMID 32417485. S2CID 218680033.
- ^ Krotulski AJ, Papsun DM, Chronister CW, Homan J, Crosby MM, Hoyer J, et al. (August 2020). "Eutylone Intoxications-An Emerging Synthetic Stimulant in Forensic Investigations". Journal of Analytical Toxicology. 45 (1): 8–20. doi:10.1093/jat/bkaa113 . PMID 33325503.
- ^ Chen HY, Chien WC, Huang MN, Fang CC, Weng TI (January 2021). "Analytically confirmed eutylone (bk-EBDB) exposure in emergency department patients". Clinical Toxicology. 59 (9): 846–848. doi:10.1080/15563650.2020.1868491. PMID 33448882. S2CID 231611658.
- ^ a b Nakamura M, Takaso M, Takeda A, Hitosugi M (September 2022). "A fatal case of intoxication from a single use of eutylone: Clinical symptoms and quantitative analysis results". Leg Med (Tokyo). 58 102085. doi:10.1016/j.legalmed.2022.102085. PMID 35537301. S2CID 248602483.
- ^ "Emerging Threat Report" (PDF). 2021.
- ^ "Tretton ämnen föreslås klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 25 September 2019. Archived from the original on 31 October 2019. Retrieved 11 November 2019.
- ^ Lists of: Scheduling Actions. Controlled Substances. Regulated Chemicals
- ^ "Federal Register :: Request Access". 10 April 2023.
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