2C-T-2

2C-T-2, also known as 4-ethylthio-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families.^{[1] [2] [3]} It was first synthesized in 1981 by Alexander Shulgin, and rated by him as one of the "magical half-dozen" most important psychedelic phenethylamines.^{[1] [4] [1]} The drug has structural and pharmacodynamic properties similar to those of 2C-T-7 ("Blue Mystic").^[1]

In Alexander Shulgin's book PiHKAL (Phenethylamines I Have Known and Loved), the dose range is listed as 12 to 25 mg orally and its duration as 6 to 8 hours.^[1] Its onset is within 1 hour and peak effects occur after 1 to 2 hours.^[1] The effects of 2C-T-2 have been described.^[1]

A potential risk of neurotoxicity from 2C-T-2 use (and 2C chemical series in general) has been shown in serotonergic and dopaminergic containing neurons, however the assay used concentrations unlikely to translate to recreational use of the compound (>50 μM). This has also been shown to be magnified in serotonergic-containing cells with combined use of 2C series drugs with alcohol, MDMA, and methamphetamine.^[5]

Severe 'intoxication' on 2C series drugs has been observed as behavior that includes: intense hallucinations, agitation, aggression, violence, dysphoria, hypertension, tachycardia, seizures, and hyperthermia.^[6]

2C-T-2 is metabolized by the monoamine oxidase (MAO) enzymes MAO-A and MAO-B.^{[7] [8]} Monoamine oxidase inhibitors (MAOIs) such as phenelzine, tranylcypromine, moclobemide, and selegiline may potentiate the effects of 2C-T-2.^{[7] [8] [9]} This may result in overdose and serious toxicity.^{[9] [7]}

The mechanism of action that produces 2C-T-2’s hallucinogenic effects is shown to be most likely a result from action as a serotonin 5-HT_2A, 5-HT_2B, and 5-HT_2C serotonin receptor agonist,^[17] a mechanism of action shared by the hallucinogenic tryptamines and phenethylamines to varying degrees.^{[18] [19]} 2C-T-2 has also shown to be a partial agonist of adrenergic receptors.^[20]

The chemical synthesis of 2C-T-2 has been described.^{[1] [2]}

Analogues of 2C-T-2 include 2C-T (2C-T-1), 2C-T-4, 2C-T-7, Aleph-2, and 25T2-NBOMe, among others.^{[1] [2]}

2C-T-2 is also a controlled substance in Argentina as well as 2C-B and 2C-I.^[21]

2C-T-2 is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015).^[22] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.^[22]

As of October 31, 2016, 2C-T-2 is a controlled substance (Schedule III) in Canada.^[23]

As of October 2015 2C-T-2 is a controlled substance in China.^[24]

2C-T-2 is classified as a narcotic drug in Finland.^[25]

The Netherlands became the first country in the world to ban 2C-T-2, and classify it as a hard drug, by law. In April, 1999, 2C-T-2 became a list I drug of the Opium Law.

Schedule I in Sweden. 2C-T-2 was first classified as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of April 1, 1999, under SFS 1999:58^[26] that made it illegal to sell or possess. The Riksdag added 2C-T-2 to Narcotic Drugs Punishments Act under Swedish schedule I ("substances, plant materials and fungi which normally do not have medical use") as of March 16, 2004, published by Medical Products Agency (MPA) in regulation LVFS 2004:3 listed as 2C-T-2, 2,5-dimetoxi-4-etyltiofenetylamin.^[27]

2C-T-2 and all other compounds featured in PiHKAL are illegal drugs in the United Kingdom.

2C-T-2 is specifically listed as a schedule I substance under SEC. 1152 of S.3187: Food and Drug Administration Safety and Innovation Act of 2012.^[28]

• 2C (psychedelics)

• 2C-T-2 - Isomer Design
• 2C-T-2 - PsychonautWiki
• 2C-T-2 - Erowid
• 2C-T-2 - PiHKAL - Erowid
• 2C-T-2 - PiHKAL - Isomer Design
• 2C-T-2: Potential Therapeutic Alternative to MDMA? - Tripsitter
• Sulfurous Samadhi: An Investigation of 2C-T-2 & 2C-T-7 - Erowid

• Drugs not assigned an ATC code
• 2C (psychedelics)
• 5-HT2A agonists
• 5-HT2B agonists
• 5-HT2C agonists
• Alexander Shulgin
• Designer drugs
• Ethylthio compounds
• O-methylated phenols
• Psychedelic phenethylamines
• Substances discovered in the 1980s
• TAAR1 modulators

• CS1 Spanish-language sources (es)
• CS1 Chinese-language sources (zh)
• CS1 Swedish-language sources (sv)
• Articles with short description
• Short description is different from Wikidata
• ECHA InfoCard ID from Wikidata
• Chemical pages without DrugBank identifier