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GTF2F1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
GTF2F1
Available structures
PDB Ortholog search: PDBe RCSB
List of PDB id codes

1F3U, 1I27, 1J2X, 1NHA, 1ONV, 2K7L, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6

Identifiers
Aliases GTF2F1 , general transcription factor IIF, polypeptide 1, 74kDa, BTF4, RAP74, TF2F1, TFIIF, general transcription factor IIF subunit 1
External IDsOMIM: 189968; MGI: 1923848; HomoloGene: 1585; GeneCards: GTF2F1; OMA:GTF2F1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human) [1]
Band 19p13.3Start6,379,572 bp [1]
End6,393,981 bp [1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr. Chromosome 17 (mouse)[2]
Band 17|17 DStart57,310,405 bp [2]
End57,318,288 bp [2]
RNA expression pattern
Bgee
Human Mouse (ortholog)
  • Cerebellum

  • cerebellar cortex

  • cerebellar hemisphere

  • left testis

  • right hemisphere of cerebellum

  • right testis

  • left ovary

  • prefrontal cortex

  • anterior pituitary

  • superior frontal gyrus
  • saccule

  • otic placode

  • otic vesicle

  • seminiferous tubule

  • neural layer of retina

  • tail of embryo

  • primitive streak

  • primary oocyte

  • yolk sac

  • genital tubercle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2962

98053

Ensembl

ENSG00000125651

ENSMUSG00000002658

UniProt

P35269

Q3THK3

RefSeq (mRNA)

NM_002096

NM_133801

RefSeq (protein)

NP_002087

NP_598562

Location (UCSC)Chr 19: 6.38 – 6.39 Mb Chr 17: 57.31 – 57.32 Mb
PubMed search[3] [4]
Wikidata

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.[5] [6]

Interactions

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GTF2F1 has been shown to interact with:

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125651Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002658Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (March 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature. 355 (6359): 464–7. Bibcode:1992Natur.355..464F. doi:10.1038/355464a0. PMID 1734284. S2CID 1241044.
  6. ^ "Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa".
  7. ^ Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593 . PMID 9765293.
  8. ^ a b c d e f Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605 . PMC 20825 . PMID 9159119.
  9. ^ Kim MK, Nikodem VM (October 1999). "hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation". Mol. Cell. Biol. 19 (10): 6833–44. doi:10.1128/MCB.19.10.6833. PMC 84680 . PMID 10490622.
  10. ^ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. doi:10.1128/MCB.17.10.6029. PMC 232452 . PMID 9315662.
  11. ^ Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (September 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. PMC 109120 . PMID 9710619.
  12. ^ Joliot V, Demma M, Prywes R (February 1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature. 373 (6515): 632–5. Bibcode:1995Natur.373..632J. doi:10.1038/373632a0. PMID 7854423. S2CID 47196160.
  13. ^ Zhu H, Joliot V, Prywes R (February 1994). "Role of transcription factor TFIIF in serum response factor-activated transcription". J. Biol. Chem. 269 (5): 3489–97. doi:10.1016/S0021-9258(17)41889-8 . PMID 8106390.
  14. ^ Dikstein R, Ruppert S, Tjian R (March 1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74". Cell. 84 (5): 781–90. doi:10.1016/s0092-8674(00)81055-7 . PMID 8625415. S2CID 18490534.
  15. ^ a b Ruppert S, Tjian R (November 1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation". Genes Dev. 9 (22): 2747–55. doi:10.1101/gad.9.22.2747 . PMID 7590250.
  16. ^ Siegert JL, Robbins PD (January 1999). "Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250". Mol. Cell. Biol. 19 (1): 846–54. doi:10.1128/MCB.19.1.846. PMC 83941 . PMID 9858607.
  17. ^ a b Malik S, Guermah M, Roeder RG (March 1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode:1998PNAS...95.2192M. doi:10.1073/pnas.95.5.2192 . PMC 19292 . PMID 9482861.
  18. ^ Fang SM, Burton ZF (May 1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding". J. Biol. Chem. 271 (20): 11703–9. doi:10.1074/jbc.271.20.11703 . PMID 8662660.

Further reading

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PDB gallery
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2 /EREBP -related factors
(0.6) Miscellaneous

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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