ELM
The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
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LIG_HP1_1

Accession:
Functional site class:
HP1 ligand
Functional site description:
Motif in proteins that interact with the chromoshadow domain of Heterochromatin-binding protein 1.
ELM Description:
Motif is a ligand to an interface formed by dimerization of two chromoshadow domains in HP1 proteins.
Pattern: P[MVLIRWY]V[MVLIAS][LM]
Pattern Probability: 0.0000338
Present in taxon: Eukaryota
Interaction Domain:
Chromo_shadow (PF01393) Chromo shadow domain (Stochiometry: 1 : 1)
PDB Structure: 1S4Z
o See 9 Instances for LIG_HP1_1
o Abstract
HP1 is a nonhistone chromosomal protein primarily associated with heterochromatin. In mammals three variants exist: HP1 alpha, HP1 beta and HP1 gamma. All have an N-terminal chromodomain (SM00298) and a C-terminal chromoshadow domain (SM00300). The HP1 chromodomain can bind to metylated lysine 9 on histone H3, while the chromoshadow domain can mediate homo-dimerisation and interaction with other proteins. The PxVxL motif was identified as a HP1-binding motif by Smothers,2000). Several chromatin modifying proteins have been shown to interact with HP1 using this motif. Structural analysis has shown that the motif interacts with a chomoshadow domain dimer (Brasher,2000).
o 4 selected references:


o 5 GO-Terms:
Biological Process:
Dna Replication (also annotated in these classes: LIG_PCNA_PIPBox_1 LIG_PCNA_TLS_4 LIG_PCNA_yPIPBox_3 LIG_RPA_C_Plants LIG_RPA_C_Vert MOD_CDK_SPK_2 MOD_CDK_SPxxK_3 MOD_Plk_2-3 )
Establishment Of Heterochromatin Silencing (also annotated in class: )
Cellular Compartment:
Nucleus (also annotated in these classes: CLV_C14_Caspase3-7 CLV_Separin_Fungi CLV_Separin_Metazoa CLV_TASPASE1 DEG_APCC_DBOX_1 DEG_APCC_KENBOX_2 DEG_APCC_TPR_1 DEG_Cend_DCAF12_1 DEG_Cend_FEM1AC_1 DEG_Cend_FEM1B_2 DEG_Cend_KLHDC2_1 DEG_Cend_TRIM7_1 DEG_COP1 DEG_COP1_1 DEG_CRL4_CDT2_1 DEG_CRL4_CDT2_2 DEG_Kelch_Keap1_1 DEG_Kelch_Keap1_2 DEG_MDM2_SWIB_1 DEG_ODPH_VHL_1 DEG_SCF_COI1_1 DEG_SCF_FBW7_1 DEG_SCF_FBW7_2 DEG_SCF_FBXO31_1 DEG_SCF_SKP2-CKS1_1 DEG_SCF_TIR1_1 DEG_SCF_TRCP1_1 DEG_SIAH_1 DEG_SPOP_SBC_1 DOC_ANK_TNKS_1 DOC_CDC14_PxL_1 DOC_CKS1_1 DOC_CYCLIN_D_Helix_1 DOC_CYCLIN_RevRxL_6 DOC_CYCLIN_RxL_1 DOC_CYCLIN_yClb1_LxF_4 DOC_CYCLIN_yClb3_PxF_3 DOC_CYCLIN_yClb5_NLxxxL_5 DOC_CYCLIN_yCln2_LP_2 DOC_MAPK_DCC_7 DOC_MAPK_FxFP_2 DOC_MAPK_gen_1 DOC_MAPK_GRA24_9 DOC_MAPK_HePTP_8 DOC_MAPK_JIP1_4 DOC_MAPK_MEF2A_6 DOC_MAPK_NFAT4_5 DOC_MAPK_RevD_3 DOC_PIKK_1 DOC_PP1_MyPhoNE_1 DOC_PP1_RVXF_1 DOC_PP1_SILK_1 DOC_PP2A_B56_1 DOC_PP2A_KARD_1 DOC_PP2B_LxvP_1 DOC_PP2B_PxIxIT_1 DOC_PP4_FxxP_1 DOC_PP4_MxPP_1 DOC_USP7_MATH_1 DOC_USP7_MATH_2 DOC_USP7_UBL2_3 DOC_WW_Pin1_4 LIG_14-3-3_CanoR_1 LIG_14-3-3_ChREBP_3 LIG_14-3-3_CterR_2 LIG_ANK_PxLPxL_1 LIG_APCC_ABBA_1 LIG_APCC_Cbox_1 LIG_APCC_Cbox_2 LIG_ARL_BART_1 LIG_ARS2_EDGEI_1 LIG_BRCT_BRCA1_1 LIG_BRCT_BRCA1_2 LIG_BRCT_MDC1_1 LIG_CaM_1-14-15-16_REV_1 LIG_CaMK_CASK_1 LIG_CORNRBOX LIG_CSL_BTD_1 LIG_CtBP_PxDLS_1 LIG_CtBP_RRT_2 LIG_DCNL_PONY_1 LIG_EF_ALG2_ABM_1 LIG_EF_ALG2_ABM_2 LIG_EH1_1 LIG_FHA_1 LIG_FHA_2 LIG_GLEBS_BUB3_1 LIG_HCF-1_HBM_1 LIG_HOMEOBOX LIG_IRF7_LxLS_2 LIG_IRFs_LxIS_1 LIG_KEPE_1 LIG_KEPE_2 LIG_KEPE_3 LIG_LEDGF_IBM_1 LIG_LSD1_SNAG_1 LIG_MAD2 LIG_Menin_MBM1_1 LIG_MLH1_MIPbox_1 LIG_MSH2_SHIPbox_1 LIG_MTR4_AIM_1 LIG_Mtr4_Air2_1 LIG_Mtr4_Trf4_1 LIG_Mtr4_Trf4_2 LIG_MYND_1 LIG_MYND_2 LIG_MYND_3 LIG_NBox_RRM_1 LIG_NRBOX LIG_Nrd1CID_NIM_1 LIG_PALB2_WD40_1 LIG_PCNA_APIM_2 LIG_PCNA_PIPBox_1 LIG_PCNA_TLS_4 LIG_PCNA_yPIPBox_3 LIG_PTAP_UEV_1 LIG_RBL1_LxSxE_2 LIG_RB_LxCxE_1 LIG_RB_pABgroove_1 LIG_REV1ctd_RIR_1 LIG_RPA_C_Plants LIG_RPA_C_Vert LIG_RRM_PRI_1 LIG_Rrp6Rrp47_Mtr4_1 LIG_Sin3_1 LIG_Sin3_2 LIG_Sin3_3 LIG_SUFU_1 LIG_SUMO_SIM_anti_2 LIG_SUMO_SIM_par_1 LIG_TPR LIG_Trf4_IWRxY_1 LIG_TRFH_1 LIG_UBA3_1 LIG_ULM_U2AF65_1 LIG_VCP_SHPBox_1 LIG_VCP_VBM_3 LIG_VCP_VIM_2 LIG_WD40_WDR5_VDV_1 LIG_WD40_WDR5_VDV_2 LIG_WD40_WDR5_WIN_1 LIG_WD40_WDR5_WIN_2 LIG_WD40_WDR5_WIN_3 LIG_WRPW_1 LIG_WRPW_2 LIG_WW_2 MOD_AAK1BIKe_LxxQxTG_1 MOD_CDC14_SPxK_1 MOD_CDK_SPK_2 MOD_CDK_SPxK_1 MOD_CDK_SPxxK_3 MOD_CK1_1 MOD_CK2_1 MOD_DYRK1A_RPxSP_1 MOD_GSK3_1 MOD_NEK2_1 MOD_NEK2_2 MOD_PIKK_1 MOD_PKA_1 MOD_PKA_2 MOD_PKB_1 MOD_PLK MOD_Plk_1 MOD_Plk_2-3 MOD_Plk_4 MOD_PRMT_GGRGG_1 MOD_ProDKin_1 MOD_SUMO_for_1 MOD_SUMO_rev_2 ELM:old_LIG_14-3-3_1 ELM:old_LIG_14-3-3_2 ELM:old_LIG_14-3-3_3 TRG_NES_CRM1_1 TRG_NESrev_CRM1_2 TRG_NLS_Bipartite_1 TRG_NLS_MonoCore_2 TRG_NLS_MonoExtC_3 TRG_NLS_MonoExtN_4 )
Heterochromatin (also annotated in class: )
Molecular Function:
Transcription Regulator (also annotated in class: )


o 9 Instances for LIG_HP1_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
Q62318 Trim28
TIF1B_MOUSE 		486 490 SGLLRKVPRVSLERLDLDLT TP 4 Mus musculus (House mouse)
1
Q13263 TRIM28
TIF1B_HUMAN 		486 490 SGLMRKVPRVSLERLDLDLT TP 6 Homo sapiens (Human)
Q9QWF0 Chaf1a
CAF1A_MOUSE 		222 226 LLFIEKVPVVVLEDILATKP TP 1 Mus musculus (House mouse)
P20193 Su(var)3-7
SUV37_DROME 		394 398 PEDAQDTPVVMMNGDVDSGD TP 1 Drosophila melanogaster (Fruit fly)
O00268 TAF4
TAF4_HUMAN 		764 768 QVTLTQTPMVALRQPHNRIM TP 1 Homo sapiens (Human)
O15164 TRIM24
TIF1A_HUMAN 		713 717 ADSTHKVPVVMLEPIRIKQE TP 2 Homo sapiens (Human)
Q9VI63 Alh
Q9VI63_DROME 		1051 1055 AVPATTSPLVVLSNQLPLNS TP 2 Drosophila melanogaster (Fruit fly)
P12956 XRCC6
XRCC6_HUMAN 		352 356 LMLMGFKPLVLLKKHHYLRP TP 2 Homo sapiens (Human)
Q13111 CHAF1A
CAF1A_HUMAN 		238 242 ILFKGKVPMVVLQDILAVRP TP 1 Homo sapiens (Human)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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