ELM - instance LIG_HP1_1 in sequence Q62318 at position 486

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002118	Q62318 Trim28 TIF1B_MOUSE	486	490	SGLLRKVPRVSLERLDLDLT	TP	---	Mus musculus (House mouse)	834

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0018	two hybrid	in vivo	Cammas,2002	support	certain	InteractionDetection
experimental	MI:0051	fluorescence technology	Cammas,2002	support	certain	InteractionDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Cammas,2002	support	certain	InteractionDetection
experimental	MI:0005	alanine scanning	in vivo/in vitro/in silico	Cammas,2002	support	certain	FeatureDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000185:
ELM Switch SWTI000185
Phosphorylation of S473 close to the Chromo shadow domain-binding motif of Transcription intermediary factor 1-beta (Trim28) by Protein kinase C delta type (Prkcd) negatively regulates its interaction with Chromobox protein homolog 1 (Cbx1), which is crucial for heterochromatin formation and maintenance. This results in relief of transcription repression and promotion of cell cycle progression.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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