Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
ALK mutants bind STAT3
Show undefined attributes
Go to Details
authored
[InstanceEdit:9724129] Rothfels, Karen, 2021年03月22日
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9712080] Rothfels, Karen, 2021年01月14日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9712079
disease
[Disease:1500689] cancer
displayName
ALK mutants bind STAT3
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
eventOf
[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-9712085] ALK mutants phosphorylate STAT3 - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-539044] STAT3 [cytosol]
[CandidateSet:R-HSA-9711944] STAT3-activating ALK mutants [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9701321] Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
[LiteratureReference:9701412] Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma
[LiteratureReference:9701338] Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma
[LiteratureReference:9701343] NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors
[LiteratureReference:9716071] EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
[LiteratureReference:9701376] Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer
[LiteratureReference:9701357] Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
[LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer
[LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
[LiteratureReference:9718441] The role of the ALK receptor in cancer biology
[LiteratureReference:9710767] Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas
[LiteratureReference:9711805] A novel KIF5B-ALK variant in nonsmall cell lung cancer
[LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease
[LiteratureReference:9701413] Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma
[LiteratureReference:9701348] Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma
[LiteratureReference:9701408] Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma
[LiteratureReference:9701292] Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
[LiteratureReference:9701315] JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells
[LiteratureReference:9701314] The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
[LiteratureReference:9723824] Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma
[LiteratureReference:9723810] Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
ALK mutants bind STAT3
normalReaction
[BlackBoxEvent:R-HSA-9701524] STAT3 is phosphorylated downstream of active ALK
output
[Complex:R-HSA-9711935] STAT3-activating ALK mutants:STAT3 [cytosol]
precedingEvent
[Reaction:R-HSA-9700181] Autophosphorylation of ALK fusions - Homo sapiens
[Reaction:R-HSA-9700186] Autophosphorylation of point mutants of ALK - Homo sapiens
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9712079
summation
[Summation:9724095] The STAT3 signaling pathway is a major downstream target of ...
Referrals
(hasEvent)
[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants
(precedingEvent)
[Reaction:R-HSA-9712085] ALK mutants phosphorylate STAT3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル