Reactome Pathway Database

Schema > Reaction > Entries

ALK mutants phosphorylate STAT3 Show undefined attributes

authored

[InstanceEdit:9724129] Rothfels, Karen, 2021年03月22日

catalystActivity

[CatalystActivity:9711943] protein tyrosine kinase activity of STAT3-activating ALK mutants:STAT3 [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:9712080] Rothfels, Karen, 2021年01月14日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 9712085

disease

[Disease:1500689] cancer

displayName ALK mutants phosphorylate STAT3

edited

[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日

eventOf

[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-9850958] pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

ALK mutants phosphorylate STAT3

output

precedingEvent

[Reaction:R-HSA-9712079] ALK mutants bind STAT3 - Homo sapiens

releaseDate 2021年06月09日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9712085

summation

[Summation:9724123] STAT3 is tyrosine phosphorylated at residue 705, and this ph...

Referrals

(precedingEvent)

[BlackBoxEvent:R-HSA-9850958] pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants

(hasEvent)

[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants

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