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Schema
>
CandidateSet
>
Entries
STAT3-activating ALK mutants [cytosol]
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compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
componentOf
[Complex:R-HSA-9712038] STAT3-activating ALK mutants:p-Y STAT3 [cytosol] - Homo sapiens
[Complex:R-HSA-9711935] STAT3-activating ALK mutants:STAT3 [cytosol] - Homo sapiens
consumedByEvent
[Reaction:R-HSA-9712079] ALK mutants bind STAT3 - Homo sapiens
created
[InstanceEdit:9711934] Rothfels, Karen, 2021年01月13日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9711944
disease
[Disease:1500689] cancer
displayName
STAT3-activating ALK mutants [cytosol]
hasCandidate
[Complex:R-HSA-9716118] EML4(1-780)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
hasMember
[Complex:R-HSA-9699991] NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
[Complex:R-HSA-9711939] KIF5B(2-575)-p-7Y ALK(1063-1620) fusion dimer [cytosol] - Homo sapiens
[Complex:R-HSA-9713501] FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9710879] CLTC(2-1634)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
[Complex:R-HSA-9710884] CLTC(2-1634)-p-7Y ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens
[Complex:R-HSA-9700018] EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens
[Complex:R-HSA-9699994] EML4(1-223)insKMSTREKNSQV -p-7Y ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens
[Complex:R-HSA-9700010] EML4(1-486)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
[Complex:R-HSA-9716117] EML4(1-569)-p-7Y ALK(1078-1620) fusion dimer [cytosol] - Homo sapiens
[Complex:R-HSA-9700020] p-7Y ALK F1174L dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9700554] p-7Y ALK K1062M dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9723883] p-7Y ALK del224-318 dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9723886] p-7Y ALK del318-782 dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9699988] p-7Y ALK F1174I dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9700563] p-7Y ALK G1128A dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9700532] p-7Y ALK I1171N dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9700612] p-7Y ALK R1192P dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9700603] p-7Y ALK F1245C dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9699979] p-7Y ALK R1275Q dimer [plasma membrane] - Homo sapiens
inDisease
true
literatureReference
[LiteratureReference:9699737] Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway
[LiteratureReference:9711805] A novel KIF5B-ALK variant in nonsmall cell lung cancer
[LiteratureReference:9713378] Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer
[LiteratureReference:9710767] Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas
[LiteratureReference:9701376] Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer
[LiteratureReference:9716071] EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
[LiteratureReference:9700372] Oncogenic mutations of ALK kinase in neuroblastoma
[LiteratureReference:9700412] Activating mutations in ALK provide a therapeutic target in neuroblastoma
[LiteratureReference:9723824] Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma
[LiteratureReference:9723810] Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma
[LiteratureReference:9723288] Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma
[LiteratureReference:9723817] Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684
maxDepth
3
modified
[InstanceEdit:9724184] Rothfels, Karen, 2021年03月22日
name
STAT3-activating ALK mutants
schemaClass
CandidateSet
species
[Species:48887] Homo sapiens
stId
R-HSA-9711944
Referrals
(input)
[Reaction:R-HSA-9712079] ALK mutants bind STAT3
(hasComponent)
[Complex:R-HSA-9712038] STAT3-activating ALK mutants:p-Y STAT3 [cytosol]
[Complex:R-HSA-9711935] STAT3-activating ALK mutants:STAT3 [cytosol]
(activeUnit)
[CatalystActivity:9711943] protein tyrosine kinase activity of STAT3-activating ALK mutants:STAT3 [cytosol]
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