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Schema
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Reaction
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Entries
Autophosphorylation of ALK fusions
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authored
[InstanceEdit:9724129] Rothfels, Karen, 2021年03月22日
catalystActivity
[CatalystActivity:9700109] protein tyrosine kinase activity of ALK fusion protein dimers [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9700180] Rothfels, Karen, 2020年09月14日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9700181
disease
[Disease:1500689] cancer
displayName
Autophosphorylation of ALK fusions
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
eventOf
[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9725009] NPM1-ALK translocates to the nucleus - Homo sapiens
[Reaction:R-HSA-9710914] ALK fusions bind GRB2 - Homo sapiens
[Reaction:R-HSA-9700190] ALK mutants bind SHC - Homo sapiens
[Reaction:R-HSA-9712088] ALK fusion proteins bind IRS - Homo sapiens
[Reaction:R-HSA-9712081] ALK fusions bind FRS - Homo sapiens
[Reaction:R-HSA-9710917] ALK fusion proteins bind PLCG1 - Homo sapiens
[Reaction:R-HSA-9712079] ALK mutants bind STAT3 - Homo sapiens
[BlackBoxEvent:R-HSA-9712078] ALK mutants bind PI3KR1 - Homo sapiens
input
[CandidateSet:R-HSA-9700079] ALK fusion protein dimers [cytosol]
3 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition
[LiteratureReference:9718441] The role of the ALK receptor in cancer biology
[LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Autophosphorylation of ALK fusions
normalReaction
[Reaction:R-HSA-201521] ALK autophosphorylation
output
3 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[CandidateSet:R-HSA-9699980] p-7Y ALK fusion protein dimers [cytosol]
precedingEvent
[Reaction:R-HSA-9700179] Ligand-independent dimerization of ALK fusions - Homo sapiens
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9700181
summation
[Summation:9718436] After partner protein-mediated dimerization, ALK fusions are...
Referrals
(precedingEvent)
[BlackBoxEvent:R-HSA-9725009] NPM1-ALK translocates to the nucleus
[Reaction:R-HSA-9710914] ALK fusions bind GRB2
[Reaction:R-HSA-9700190] ALK mutants bind SHC
[Reaction:R-HSA-9712088] ALK fusion proteins bind IRS
[Reaction:R-HSA-9712081] ALK fusions bind FRS
[Reaction:R-HSA-9710917] ALK fusion proteins bind PLCG1
[Reaction:R-HSA-9712079] ALK mutants bind STAT3
[BlackBoxEvent:R-HSA-9712078] ALK mutants bind PI3KR1
(hasEvent)
[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants
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