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BlackBoxEvent
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Entries
ALK mutants bind PI3KR1
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authored
[InstanceEdit:9724129] Rothfels, Karen, 2021年03月22日
category
omitted
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9712080] Rothfels, Karen, 2021年01月14日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9712078
disease
[Disease:1500689] cancer
displayName
ALK mutants bind PI3KR1
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
eventOf
[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-9712083] ALK mutants bind PI3KCA - Homo sapiens
input
[CandidateSet:R-HSA-9711929] PI3K-binding ALK mutants [cytosol]
[EntityWithAccessionedSequence:R-HSA-74789] PIK3R1 [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9699737] Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway
[LiteratureReference:9699732] NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner
[LiteratureReference:9699745] Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway
[LiteratureReference:201541] Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
[LiteratureReference:9711805] A novel KIF5B-ALK variant in nonsmall cell lung cancer
[LiteratureReference:9710767] Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas
[LiteratureReference:9711768] Kinase fusions are frequent in Spitz tumours and spitzoid melanomas
[LiteratureReference:9716071] EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
[LiteratureReference:9713378] Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer
[LiteratureReference:9700372] Oncogenic mutations of ALK kinase in neuroblastoma
[LiteratureReference:9723288] Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma
[LiteratureReference:9700412] Activating mutations in ALK provide a therapeutic target in neuroblastoma
[LiteratureReference:9723851] Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
[LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer
[LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
[LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition
[LiteratureReference:9723824] Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma
[LiteratureReference:9723810] Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma
[LiteratureReference:9724958] The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
ALK mutants bind PI3KR1
output
[Complex:R-HSA-9711928] ALK mutants:PIK3R1 [cytosol]
precedingEvent
[Reaction:R-HSA-9700181] Autophosphorylation of ALK fusions - Homo sapiens
[Reaction:R-HSA-9700186] Autophosphorylation of point mutants of ALK - Homo sapiens
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9712078
summation
[Summation:9724127] Various ALK fusions and point mutants have been shown to for...
updateTrackers
[UpdateTracker:9853204] Update Tracker - [BlackBoxEvent:9712078] ALK mutants bind PI3KR1 - v87:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9853204] Update Tracker - [BlackBoxEvent:9712078] ALK mutants bind PI3KR1 - v87:[modifyText]
(hasEvent)
[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants
(precedingEvent)
[Reaction:R-HSA-9712083] ALK mutants bind PI3KCA
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