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Schema
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BlackBoxEvent
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Entries
STAT3 is phosphorylated downstream of active ALK
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authored
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
category
uncertain
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:9701523] Rothfels, Karen, 2020年09月26日
dbId
9701524
displayName
STAT3 is phosphorylated downstream of active ALK
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
eventOf
[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent
[Reaction:R-HSA-9701525] p-Y705,S727-STAT3 dimerizes - Homo sapiens
input
[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-539044] STAT3 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9701321] Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
[LiteratureReference:9701412] Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma
[LiteratureReference:9701338] Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma
[LiteratureReference:9701343] NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors
[LiteratureReference:9701357] Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
[LiteratureReference:9843053] Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells
[LiteratureReference:9843020] Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells
[LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer
[LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease
[LiteratureReference:9701413] Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma
[LiteratureReference:9701348] Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma
[LiteratureReference:9701408] Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma
[LiteratureReference:9701292] Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
[LiteratureReference:9701315] JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells
[LiteratureReference:9701314] The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
STAT3 is phosphorylated downstream of active ALK
orthologousEvent
[BlackBoxEvent:R-GGA-9701524] STAT3 is phosphorylated downstream of active ALK - Gallus gallus
[BlackBoxEvent:R-SSC-9701524] STAT3 is phosphorylated downstream of active ALK - Sus scrofa
[BlackBoxEvent:R-BTA-9701524] STAT3 is phosphorylated downstream of active ALK - Bos taurus
[BlackBoxEvent:R-CFA-9701524] STAT3 is phosphorylated downstream of active ALK - Canis familiaris
[BlackBoxEvent:R-RNO-9701524] STAT3 is phosphorylated downstream of active ALK - Rattus norvegicus
[BlackBoxEvent:R-MMU-9701524] STAT3 is phosphorylated downstream of active ALK - Mus musculus
output
[EntityWithAccessionedSequence:R-HSA-539048] p-Y705,S727-STAT3 [cytosol]
precedingEvent
[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
[InstanceEdit:9852935] Turner, Suzanne, 2023年11月08日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9701524
summation
[Summation:9701516] STAT3 is phosphorylated at tyrosine 705 downstream of active...
updateTrackers
[UpdateTracker:9853301] Update Tracker - [BlackBoxEvent:9701524] STAT3 is phosphorylated downstream of active ALK - v87:[addLiteratureReference, add_removeInput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9853301] Update Tracker - [BlackBoxEvent:9701524] STAT3 is phosphorylated downstream of active ALK - v87:[addLiteratureReference, add_removeInput, modifyText]
(normalReaction)
[Reaction:R-HSA-9712079] ALK mutants bind STAT3
(hasEvent)
[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)
[Reaction:R-HSA-9701525] p-Y705,S727-STAT3 dimerizes
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