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Entries
mRNA Splicing - Major Pathway
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authored
[InstanceEdit:72076] Krainer, AR, 2003年06月05日 08:30:23
[InstanceEdit:75078] Joshi-Tope, G, 2003年08月22日 11:27:00
[InstanceEdit:9769907] May, Bruce, 2022年03月22日
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:72076] Krainer, AR, 2003年06月05日 08:30:23
dbId
72163
displayName
mRNA Splicing - Major Pathway
doi
10.3180/R-HSA-72163.3
edited
[InstanceEdit:9769907] May, Bruce, 2022年03月22日
eventOf
[Pathway:R-HSA-72172] mRNA Splicing - Homo sapiens
followingEvent
[Pathway:R-HSA-72187] mRNA 3'-end processing - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:77621] mRNA splicing, via spliceosome
hasDiagram
false
hasEHLD
false
hasEvent
[BlackBoxEvent:R-HSA-9770119] Formation of the Spliceosomal E complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770129] Formation of the Spliceosomal A complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770132] Formation of the Spliceosomal Pre-B complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770142] Formation of the Spliceosomal B complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770145] Formation of the Spliceosomal Bact complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770131] Formation of the Spliceosomal B* complex - Homo sapiens
[BlackBoxEvent:R-HSA-9794542] Formation of the Spliceosomal C complex containing intron lariat - Homo sapiens
[BlackBoxEvent:R-HSA-9770141] Formation of the Spliceosomal C* complex - Homo sapiens
[BlackBoxEvent:R-HSA-9770236] Formation of the Spliceosomal P complex and exon ligation - Homo sapiens
[BlackBoxEvent:R-HSA-9770847] Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) - Homo sapiens
[Reaction:R-HSA-9772351] Disassembly of the Intron Lariat Spliceosome (new) - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023年03月29日
literatureReference
[LiteratureReference:9709004] Cryo-EM snapshots of the human spliceosome reveal structural adaptions for splicing regulation
[LiteratureReference:9773071] How Is Precursor Messenger RNA Spliced by the Spliceosome?
[LiteratureReference:9773068] RNA Splicing by the Spliceosome
[LiteratureReference:9773072] A Day in the Life of the Exon Junction Complex
[LiteratureReference:9773074] Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome
[LiteratureReference:9773073] Spliceosome structure and function
[LiteratureReference:9773231] Intron-exon structures of eukaryotic model organisms
[LiteratureReference:9771902] A compensatory base change in U1 snRNA suppresses a 5' splice site mutation
[LiteratureReference:9770231] Association of U2 snRNP with the spliceosomal complex E
[LiteratureReference:9770219] Functional association of U2 snRNP with the ATP-independent spliceosomal complex E
[LiteratureReference:72109] Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.
[LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome.
[LiteratureReference:8865895] Dynamic protein-protein interaction wiring of the human spliceosome
[LiteratureReference:8850757] Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs
[LiteratureReference:8865896] Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins
[LiteratureReference:9771897] Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition
[LiteratureReference:9771907] Noncanonical registers and base pairs in human 5' splice-site selection
[LiteratureReference:9771890] Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing
[LiteratureReference:9771893] U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction
[LiteratureReference:5420912] Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex
[LiteratureReference:9770232] Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
[LiteratureReference:5566497] Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes
[LiteratureReference:9771903] Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome
[LiteratureReference:9770261] Stoichiometries of U2AF35, U2AF65 and U2 snRNP reveal new early spliceosome assembly pathways
[LiteratureReference:9771887] Molecular architecture of the human 17S U2 snRNP
[LiteratureReference:9771906] Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles
[LiteratureReference:927736] A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex
[LiteratureReference:8850665] Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA
[LiteratureReference:9772622] Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28
[LiteratureReference:9770241] A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity
[LiteratureReference:9769529] Structures of the human pre-catalytic spliceosome and its precursor spliceosome
[LiteratureReference:9769531] Mechanism of 5' splice site transfer for human spliceosome activation
[LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
[LiteratureReference:9769520] Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation
[LiteratureReference:9772614] The 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase site
[LiteratureReference:5566502] Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions
[LiteratureReference:8865916] Isolation of an active step I spliceosome and composition of its RNP core
[LiteratureReference:9772724] Exon, intron and splice site locations in the spliceosomal B complex
[LiteratureReference:6806809] Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis
[LiteratureReference:9770574] Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count
[LiteratureReference:9772624] Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation
[LiteratureReference:9769580] Structure of the human activated spliceosome in three conformational states
[LiteratureReference:6806782] Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein
[LiteratureReference:9772623] The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro
[LiteratureReference:5420900] Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry
[LiteratureReference:9770594] Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method
[LiteratureReference:9769577] Structure and Conformational Dynamics of the Human Spliceosomal B
act
Complex
[LiteratureReference:9770585] Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes
[LiteratureReference:72132] Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
[LiteratureReference:5566504] Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome
[LiteratureReference:157383] 5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly
[LiteratureReference:8850870] Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing
[LiteratureReference:9772093] Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay
[LiteratureReference:9772088] Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly
[LiteratureReference:8865939] CWC22 connects pre-mRNA splicing and exon junction complex assembly
[LiteratureReference:9772613] Structure of a human catalytic step I spliceosome
[LiteratureReference:9772742] The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis
[LiteratureReference:9772746] Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing
[LiteratureReference:6806800] Rearrangements within human spliceosomes captured after exon ligation
[LiteratureReference:9770783] An Atomic Structure of the Human Spliceosome
[LiteratureReference:8984694] The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
[LiteratureReference:9769585] A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation
[LiteratureReference:9769600] Structures of the human spliceosomes before and after release of the ligated exon
[LiteratureReference:9772736] A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome
[LiteratureReference:9770592] Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment
[LiteratureReference:5566492] Isolation and characterization of post-splicing lariat-intron complexes
[LiteratureReference:9772987] Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion
[LiteratureReference:9771082] Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release
[LiteratureReference:9772984] TFIP11 interacts with mDEAH9, an RNA helicase involved in spliceosome disassembly
[LiteratureReference:9772981] Identification of a novel component C2ORF3 in the lariat-intron complex: lack of C2ORF3 interferes with pre-mRNA splicing via intron turnover pathway
[LiteratureReference:9772985] Structural basis for DEAH-helicase activation by G-patch proteins
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
mRNA Splicing - Major Pathway
pre-mRNA splicing
U2 Dependent Splicing
orthologousEvent
[Pathway:R-PFA-72163] mRNA Splicing - Major Pathway - Plasmodium falciparum
[Pathway:R-SPO-72163] mRNA Splicing - Major Pathway - Schizosaccharomyces pombe
[Pathway:R-DDI-72163] mRNA Splicing - Major Pathway - Dictyostelium discoideum
[Pathway:R-CEL-72163] mRNA Splicing - Major Pathway - Caenorhabditis elegans
[Pathway:R-DME-72163] mRNA Splicing - Major Pathway - Drosophila melanogaster
[Pathway:R-GGA-72163] mRNA Splicing - Major Pathway - Gallus gallus
[Pathway:R-XTR-72163] mRNA Splicing - Major Pathway - Xenopus tropicalis
[Pathway:R-DRE-72163] mRNA Splicing - Major Pathway - Danio rerio
[Pathway:R-SSC-72163] mRNA Splicing - Major Pathway - Sus scrofa
[Pathway:R-BTA-72163] mRNA Splicing - Major Pathway - Bos taurus
[Pathway:R-CFA-72163] mRNA Splicing - Major Pathway - Canis familiaris
[Pathway:R-RNO-72163] mRNA Splicing - Major Pathway - Rattus norvegicus
[Pathway:R-MMU-72163] mRNA Splicing - Major Pathway - Mus musculus
releaseDate
2004年07月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9818818] Charenton, Cl駑ent, 2022年10月20日
revised
[InstanceEdit:9769907] May, Bruce, 2022年03月22日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-72163
summation
[Summation:9773064] Eukaryotic genes are transcribed to yield pre-mRNAs that are...
updateTrackers
[UpdateTracker:9928477] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v91:[removeHasEvent]
[UpdateTracker:9783301] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v57:[updateContainedRLE]
[UpdateTracker:9783517] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v56:[updateContainedRLE]
[UpdateTracker:9790388] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v33:[addHasEvent]
[UpdateTracker:9846898] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v83:[addLiteratureReference, add_removeHasEvent, add_removeSummation]
[UpdateTracker:9846781] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v84:[modifyText]
[UpdateTracker:9774821] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v81:[updateContainedRLE]
[UpdateTracker:9775172] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v80:[updateContainedRLE]
[UpdateTracker:9775673] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v78:[updateContainedRLE]
[UpdateTracker:9784010] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v55:[updateContainedRLE]
[UpdateTracker:9786512] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v49:[updateContainedRLE]
[UpdateTracker:9781554] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v60:[updateContainedRLE]
[UpdateTracker:9784619] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v53:[updateContainedRLE]
Referrals
(precedingEvent)
[Pathway:R-HSA-72187] mRNA 3'-end processing
(hasEvent)
[Pathway:R-HSA-72172] mRNA Splicing
(updatedInstance)
[UpdateTracker:9928477] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v91:[removeHasEvent]
[UpdateTracker:9783301] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v57:[updateContainedRLE]
[UpdateTracker:9783517] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v56:[updateContainedRLE]
[UpdateTracker:9790388] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v33:[addHasEvent]
[UpdateTracker:9846898] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v83:[addLiteratureReference, add_removeHasEvent, add_removeSummation]
[UpdateTracker:9846781] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v84:[modifyText]
[UpdateTracker:9774821] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v81:[updateContainedRLE]
[UpdateTracker:9775172] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v80:[updateContainedRLE]
[UpdateTracker:9775673] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v78:[updateContainedRLE]
[UpdateTracker:9784010] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v55:[updateContainedRLE]
[UpdateTracker:9786512] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v49:[updateContainedRLE]
[UpdateTracker:9781554] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v60:[updateContainedRLE]
[UpdateTracker:9784619] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v53:[updateContainedRLE]
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