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Schema
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BlackBoxEvent
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Entries
Formation of the Spliceosomal B complex
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authored
[InstanceEdit:9769907] May, Bruce, 2022年03月22日
catalystActivity
[CatalystActivity:9770929] RNA helicase activity of Spliceosomal Pre-B complex [nucleoplasm]
category
uncertain
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9770146] May, Bruce, 2022年03月24日
dbId
9770142
deleted
[Deleted:9830324] Deletion of instance: 72127
displayName
Formation of the Spliceosomal B complex
edited
[InstanceEdit:9769907] May, Bruce, 2022年03月22日
eventOf
[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9770145] Formation of the Spliceosomal Bact complex - Homo sapiens
input
[DefinedSet:R-HSA-9770781] ASAP complex, PSAP complex [nucleoplasm]
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2396419] MFAP1 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8867889] PQBP1 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8867897] PRPF38A [nucleoplasm]
[Complex:R-HSA-9769523] RES complex [nucleoplasm]
[Complex:R-HSA-9769528] Spliceosomal Pre-B complex [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770255] UBL5 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8867887] WBP11 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8867895] WBP4 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770248] ZMAT2 [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome.
[LiteratureReference:5566502] Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions
[LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
[LiteratureReference:9769580] Structure of the human activated spliceosome in three conformational states
[LiteratureReference:6806809] Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis
[LiteratureReference:9770574] Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count
[LiteratureReference:8865916] Isolation of an active step I spliceosome and composition of its RNP core
[LiteratureReference:9772624] Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation
[LiteratureReference:9770241] A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity
[LiteratureReference:9772622] Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28
[LiteratureReference:9772614] The 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase site
[LiteratureReference:9772724] Exon, intron and splice site locations in the spliceosomal B complex
[LiteratureReference:9818098] Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site
[LiteratureReference:9769531] Mechanism of 5' splice site transfer for human spliceosome activation
maxDepth
1
modified
[InstanceEdit:10201029] Weiser, Joel, 2025年08月27日
name
Formation of the Spliceosomal B complex
orthologousEvent
[BlackBoxEvent:R-MMU-9770142] Formation of the Spliceosomal B complex - Mus musculus
[BlackBoxEvent:R-RNO-9770142] Formation of the Spliceosomal B complex - Rattus norvegicus
[BlackBoxEvent:R-CFA-9770142] Formation of the Spliceosomal B complex - Canis familiaris
output
[SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-71879] DDX23 [nucleoplasm]
[SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-8867890] PRPF40A [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769525] PRPF4B [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770250] RBM25 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9770254] RBM39 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9769526] RBM42 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-72049] RBM5 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-4615999] SART1 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-6806778] SNRNP27 [nucleoplasm]
[Complex:R-HSA-9770126] Spliceosomal B complex [nucleoplasm]
[Complex:R-HSA-71917] U1 snRNP [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-6806793] USP39 [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-9770132] Formation of the Spliceosomal Pre-B complex - Homo sapiens
releaseDate
2022年12月07日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9818818] Charenton, Cl駑ent, 2022年10月20日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9770142
summation
[Summation:9771074] The DDX23 RNA helicase (homolog of yeast Prp28) binds ATP to...
Referrals
(precedingEvent)
[BlackBoxEvent:R-HSA-9770145] Formation of the Spliceosomal Bact complex
(hasEvent)
[Pathway:R-HSA-72163] mRNA Splicing - Major Pathway
(replacementInstances)
[Deleted:9830324] Deletion of instance: 72127
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